FXR

Farnesoid X receptor (FXR) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. FXR regulates the expression of various genes by binding to DNA either as a monomer or a heterodimer with the common partner for NRs, retinoid x receptor (RXR), to FXR response elements. Two known FXR genes exist, the FXRα and FXRβ.

FXR is mainly expressed in liver and small intestine, where it plays an important role in bile acid, lipid, and glucose metabolism. FXR affects several metabolic pathways through its specific target genes, regulating bile acid (BA) synthesis and homeostasis, glucose and lipid metabolism, also exhibiting a crucial role in intestinal bacterial growth and liver regeneration.

FXR 相关产品（26）

货号	产品名	Cas
PL01069	(-)-PX20606 trans isomer	1268244-88-7
PL01204	BAR502	1612191-86-2
PL05137	Chenodeoxycholic acid-13C	52918-92-0
PL05136	Chenodeoxycholic Acid-d4	99102-69-9
PC14943	Chenodeoxycholic Acid.	474-25-9
PL01743	Cilofexor	1418274-28-8
PL01844	DY268	1609564-75-1
PL03436	EDP-305	1933507-63-1
PL02211	Gly-β-MCA	66225-78-3
PL03468	Glyco-Obeticholic acid	863239-60-5
PC14933	GW4064	278779-30-9
PL02666	INT-767	1000403-03-1
PL01456	LY2562175	1103500-20-4
PL03799	NDB	1660153-08-1
PL01748	Nidufexor	1773489-72-7
PL02533	Obeticholic Acid-d4
PL02532	Obeticholic acid-d5	1992000-80-2
PL01068	PX20606 trans racemate	1268244-85-4
PC14744	T0901317	293754-55-9
PL03467	Tauro-Obeticholic acid	863239-61-6