MAT

Methionine adenosyltransferases (MATs), also known as S-Adenosylmethionine synthetase, are essential enzymes for life as they catalyzes the synthesis of one of the most important and pivotal biological molecules, S-adenosyl-methionine. S-adenosyl-methionine is the biological methyl donor required for a plethora of reactions within the cell.Mammalian systems express two genes, MAT1A and MAT2A, which encode for MATα1 and MATα2, the catalytic subunits of the MAT isoenzymes, respectively. A third gene MAT2B, encodes a regulatory subunit known as MATβ which controls the activity of MATα2. MAT1A, which is mainly expressed in hepatocytes, maintains the differentiated state of these cells, whilst MAT2A and MAT2B are expressed in extrahepatic tissues as well as non-parenchymal cells of the liver (e.g., hepatic stellate and Kupffer cells).

MAT 相关产品（9）

货号	产品名	Cas	产品描述
PL07104	AG-270	2201056-66-6	AG-270 是非竞争性的、首创的、可逆的、具有口服活性的 MAT2A 变构抑制剂，其 IC50 值为 14 nM。
PL07101	AGI-24512	2201066-53-5	AGI-24512 是一种蛋氨酸腺苷转移酶 2α (MAT2A) 抑制剂，IC50 为 8 nM。AGI-24512 触发 DNA 损伤反应。AGI-24512 可阻断 MTAP 缺失的癌细胞体外增殖。AGI-24512可用于抗癌研究。
PL07100	FIDAS-5	1391934-98-7	FIDAS-5 是一种有效的口服活性的甲硫氨酸腺苷转移酶 2A (MAT2A) 抑制剂，IC50 为 2.1 μM。FIDAS-5 与 S-腺苷甲硫氨酸 (SAM) 有效竞争 MAT2A 结合，并具有抗癌活性。
PL07096	MAT2A inhibitor 1	2201057-10-3	MAT2A inhibitor 1 是甲硫氨酸腺苷转移酶 2A (MATA2 ) 抑制剂，其 IC50 值小于 100 nM。
PL07099	MAT2A inhibitor 2	13299-99-5	MAT2A inhibitor 2 是甲硫氨酸腺苷转移酶2A (MAT2A) 的抑制剂。
PL07097	MAT2A inhibitor 3	2439271-82-4	MAT2A inhibitor 3 是一种甲硫氨酸腺苷转移酶 2A (MAT2A) 抑制剂，IC50 值为 <200 nM。MAT2A inhibitor 3 可用于癌症研究。详细信息请参考专利文献 WO2020123395A1 中的化合物 24。
PL07103	MAT2A inhibitor 4	1391934-91-0	MAT2A inhibitor 4 是甲硫氨酸 S- 腺苷转移酶 -2 催化亚基 (MAT2A) 的抑制剂。MAT2A inhibitor 4 可用于癌症研究。
PL07098	MAT2A-IN-9	2439277-80-0	MAT2A-IN-9 (compound 167) 是一种 2-oxoquinazoline 衍生物，是一种有效的MAT2A (蛋氨酸腺苷转移酶 2A) 抑制剂。
PL07102	PF-9366	72882-78-1	PF-9366 是一种有效的甲硫氨酸腺苷转移酶 (Mat2A) 抑制剂，IC50 值和 Kd 值分别为 420 nM 和 170 nM。