FIDAS-5|1391934-98-7|-陌孚医药/Medlife

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FIDAS-5

目录号: PL07100 纯度: ≥98%

CAS No. :1391934-98-7

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PL07100-500mg	500mg	询价	询价
PL07100-1g	1g	询价	询价

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中文名称	FIDAS-5
英文名称	FIDAS-5
英文别名	FIDAS-5;(E)-4-(2-chloro-6-fluorostyryl)-N-methylaniline;BDBM102425;NSC783764;Fluorinated N,N-Dialkylaminostilbenes 5;4-[(E)-2-(2-chloro-6-fluorophenyl)ethenyl]-N-methylaniline
Cas No.	1391934-98-7
分子式	C₁₅H₁₃ClFN
分子量	261.72
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	FIDAS-5 是一种有效的口服活性的甲硫氨酸腺苷转移酶 2A (MAT2A) 抑制剂，IC₅₀ 为 2.1 μM。FIDAS-5 与 S-腺苷甲硫氨酸 (SAM) 有效竞争 MAT2A 结合，并具有抗癌活性。
生物活性	FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC 50 of 2.1 μM. FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities.
性状	Solid
IC50 & Target[1][2]	IC50: 2.1 μM (Methionine S-adenosyltransferase 2A (MAT2A))
体外研究(In Vitro)	FIDAS-5 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells. FIDAS-5 (3 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-5 induces the expression of cell cycle inhibitor, p21. FIDAS-5 (3 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	FIDAS-5 (20 mg/kg; oral gavage; daily; for two weeks; athymic nude mice) treatment significantly inhibits the growth of xenograft tumors, with minimal difference in body weight. Mice are treated with FIDAS-5 (20 mg/kg) for 1 week. The liver SAM levels are significantly reduced. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803.

溶解度数据	In Vitro: DMSO : 125 mg/mL (477.61 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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