ALCAM (CD166)，一种细胞表面糖蛋白，是免疫球蛋白超家族的细胞粘附分子。ALCAM 在多种细胞类型表达，例如白细胞和内皮细胞 (EC)。ALCAM 可以结合 T 细胞表达的清道夫受体 CD6、内皮 L1CAM 和半乳糖凝集素 8。ALCAM 调节多种病理生理过程，包括 T 细胞活化、白细胞运输和血管生成。ALCAM 是一种癌症标志物，可通过控制细胞增殖、粘附、迁移和侵袭促进肿瘤生长。
ALCAM (CD166), a cell surface glycoprotein, is a cell adhesion molecule of the immunoglobulin superfamily. ALCAM is expressed by various cell types, such as leukocytes and endothelial cells (ECs). ALCAM can bind to the T cell-expressed scavenger receptor CD6, endothelial L1CAM, and galectin-8. ALCAM regulates diverse pathophysiological processes, including T cell activation, leukocyte trafficking, and angiogenesis. ALCAM is a prognostic marker of cancers. ALCAM promotes tumor growth by controlling cell proliferation, adhesion, migration and invasion.
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