Vascular endothelial growth factors (VEGFs) are a family of secreted polypeptides that are crucial to the normal development and maintenance of the vascular and lymphatic systems. VEGF stimulates endothelial cells to degrade extracellular matrix, proliferate, migrate, and form tubes, and acts as an endothelial cell survival factor. VEGF also increases vascular permeability. So far, VEGF family includes VEGF-A, VEGF-B, VEGF-C, VEGF-D (FIGF), VEGF-Es, and placenta growth factor (PlGF). VEGFs have been found in all vertebrate species so far examined and are highly conserved between species. The biological functions of the VEGFs are mediated by VEGFRs (VEGFR1, VEGFR2, and VEGFR3), a family of cognate protein tyrosine kinase receptors, and two non-protein kinase co-receptors known as neuropilins (Neuropilin-1 and Neuropilin-2).
货号 | 产品名 | Cas | 产品描述 |
---|---|---|---|
PL12580 | (+)-SHIN1 | 2443966-90-1 | (+)-SHIN1 ((+)-RZ-2994) 是 SHIN1 的活性 (+) 对映体。 |
PL12697 | (+)-TK216 | 1903783-77-6 | (+)-TK216 是 TK216 (HY-122903) 的对映异构体。TK216 是一种口服有效的 E26 转录因子 (ETS) 抑制剂。 |
PL12571 | (-)-SHIN1 | 2444764-09-2 | (-)-SHIN1 ((-)-RZ-2994) 是 SHIN1 的非活性 (+) 对映体。 |
PL12974 | (1R,2S)-Xeruborbactam disodium | 2170836-14-1 | (1R,2S)-Xeruborbactam ((1R,2S)-QPX7728) disodium 是一种硼酸衍生物。 |
PL12560 | (1S)-Calcitriol | 61476-45-7 | (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) 是 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) 的天然代谢产物。(1S)-Calcitriol 表现出有效的维生素 D 受体 (VDR) 介导的作用,例如抑制角质形成细胞生长或抑制甲状旁腺激素分泌。 |
PL12928 | (2-Fluoro-4-biphenyl)acetic acid-d5 | 2733149-72-7 | (2-Fluoro-4-biphenyl)acetic acid-d5 是 (2-Fluoro-4-biphenyl)acetic acid 的氘代物。 |
PL12561 | (24S)-24,25-Dihydroxyvitamin D3 | 55700-58-8 | (24S)-24,25-Dihydroxyvitamin D3 ((24S)-24,25-Dihydroxycholecalciferol) 是维生素 D3 的一种非活性形式,它经过不同程度的羟基化作用形成活性维生素 D3 类似物。 |
PL12946 | (2R,2'R)-4,4'-Disulfanediylbis(2-aminobutanoic acid) | 6027-15-2 | (2R,2'R)-4,4'-Disulfanediylbis(2-aminobutanoic acid) 是一种半胱氨酸衍生物。 |
PL12911 | (2S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid | 138797-71-4 | (2S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid 是一种苏氨酸衍生物。 |
PL12746 | (2S)-Methyl 2-(2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoate | 402958-95-6 | (2S)-Methyl 2-(2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoate 是一种缬氨酸衍生物。 |
PL13017 | (2S,4R)-1-((9H-Fluoren-9-yl)methyl) 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate | 122350-59-8 | (2S,4R)-1-((9H-Fluoren-9-yl)methyl) 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 是一种脯氨酸衍生物。 |
PL12707 | (3S,4R,5S)-rel-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxylic acid | 1219086-89-1 | D-Proline, 3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-, (3S,4R,5S)-rel- 是一种脯氨酸衍生物。 |
PL13007 | (4S)-1-Boc-4-amino-D-proline | 132622-78-7 | (4S)-1-Boc-4-amino-D-proline 是一种可用于合成化合物的氨基酸衍生物。 |
PL12684 | (E)-2-Methyl-2-pentenoic acid | 16957-70-3 | (E)-2-Methyl-2-pentenoic acid 可用来作为合成具有细胞毒性的天然产物 Lactimidomycin 的组分。 |
PC16113 | (E)-FeCP-oxindole | 884338-18-5 | VEGFR-2抑制剂 |
PL12467 | (E/Z)-Capsaicin-d3 | 1185237-43-7 | (E/Z)-Capsaicin-d3 是 (E/Z)-Capsaicin 的氘代物。 |
PL13008 | (R)-1-Benzylpyrrolidine-2-carboxylic acid | 56080-99-0 | (R)-1-Benzylpyrrolidine-2-carboxylic acid 是一种脯氨酸衍生物。 |
PL13085 | (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(furan-2-yl)propanoic acid | 220497-85-8 | (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(furan-2-yl)propanoic acid 是一种丙氨酸衍生物。 |
PL12678 | (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-3-yl)propanoic acid | 220497-90-5 | (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-3-yl)propanoic acid 是一种丙氨酸衍生物。 |
PL13078 | (R)-2-(((Benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid | 70874-05-4 | (R)-2-(((Benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid 是一种亮氨酸衍生物。 |