MTP

Microsomal triglyceride transfer protein (MTP) is a heterodimer chaperone consisting of a 97-kDa lipid-binding and -transfer subunit and a 55-kDa protein disulfide isomerase (PDI). MTP was first identified as an endoplasmic reticulum (ER) resident protein that helps in the transfer of neutral lipids to nascent apolipoprotein B (apoB). MTP is predominantly expressed in hepatocytes and enterocytes and is required for the assembly and secretion of VLDL and chylomicrons by the liver and intestine, respectivel. Its critical role in the assembly and secretion of apoB-containing lipoproteins was identified in abetalipoproteinemia patients who have mutations in MTP and completely lack apoB-containing lipoproteins in the circulation. It has been established now that MTP not only is involved in the transfer of neutral lipids but also plays a role in cholesterol ester and cluster of differentiation 1d (CD1d) biosynthesis. Besides neutral lipids, MTP may also help in the transfer of sphingolipids such as ceramides and sphingomyelin to the apoB-containing lipoproteins.

MTP 相关产品（2）

货号	产品名	Cas	产品描述
PL07179	CP-346086	186390-48-7	CP-346086 是一种有效和具有口服活性的微粒体甘油三酯转移蛋白 (MTP) 抑制剂，对人和啮齿动物 MTP 的 IC50 为 2.0 nM。CP-346086 可在体内降低血浆胆固醇和甘油三酯。
PL07178	Dirlotapide	481658-94-0	Dirlotapide (CP742033) 是一种选择性的微粒体甘油三酯转运蛋白 (MTP) 抑制剂，可以减轻糖尿病狗的体重。