Hexokinase

Hexokinases (HK) play a central role in cellular glucose metabolism. Hexokinasescatalyse the first obligatory step of glucose metabolism, the ATP-dependent phosphorylation of glucose (Glc) to yield glucose-6-phosphate (Glc-6-P). In addition to maintaining the downhill concentration gradient that permits facilitated glucose entry into cells, this reaction constitutes the first step of all major pathways of glucose utilization, including glycolysis, the pentose phosphate pathway, (PPP) and glycogenesis. As such hexokinases are uniquely positioned to influence the extent and direction of glucose flux within the cell. The PPP represents the principal cellular source of NADPH and plays important roles in redox homeostasis, anabolism and nucleotide synthesis (Rib-5-P, ribulose 5-phosphate). Similarly, glycolysis and glycogenesis play important roles in energy metabolism and storage, respectively. Other important cellular functions, including hexosamine and nucleotide sugar generation for glycosaminoglycan and glycoprotein biosynthesis, also require Glc-6-P as a precursor (UDP-Glc, uridine diphosphate glucose; UDP-GlcNAc, uridine diphosphate N-acetylglucosamine).

Hexokinase 相关产品（1）

货号	产品名	Cas	产品描述
PC14899	2-Deoxy-D-glucose.	154-17-6	醣酵解的抑制剂，2-Deoxy-D-glucose 是一种葡萄糖类似物，为葡萄糖代谢抑制剂，通过作用于己糖激酶 (hexokinase) 来抑制糖酵解。