MyD88 (Myeloid differentiation primary response gene 88) is a protein that, in humans, is encoded by the MYD88 gene. Available evidence suggests that MYD88 is dispensable for human resistance to common viral infections and to all but a few pyogenic bacterial infections, demonstrating a major difference between mouse and human immune responses. MyD88 is an essential adaptor protein in the IL-1R1 signaling pathway. MyD88 may define a family of signal transduction molecules with an ancestral function in the activation of the immune system. MyD88 functions as a pure adaptor linking the IL-1R1 to downstream IRAK kinases. Mutation in MYD88 at position 265 leading to a change from leucine to proline have been identified in many human lymphomas including ABC subtype of Diffuse Large B-cell Lymphoma and Waldenstrom's Macroglobulinemia.
货号 | 产品名 | Cas | 产品描述 |
---|---|---|---|
PC14798 | ST 2825 | 894787-30-5 | |
PL07597 | T6167923 | 2437475-16-4 | |
PL07598 | TJ-M2010-5 | 1357471-57-8 | |
PL07596 | TLR1 | 566914-00-9 |