S-Nitrosoglutathione reductase (GSNOR) is a member of the alcohol dehydrogenase family (ADH) that regulates the levels of S-nitrosothiols (SNOs) through catabolism of S-nitrosoglutathione (GSNO).
GSNOR reduces the nitric oxide (NO) adduct S-nitrosoglutathione (GSNO), an essential reservoir for NO bioactivity. In plants, GSNOR has been found to be important in resistance to bacterial and fungal pathogens. GSNOR is ubiquitously expressed and catalyzes denitrosylation of GSNO, thereby downregulating protein S-nitrosylation in β-cells.
GSNOR activity appears to be necessary for normal development and fertility under optimal growth conditions.
| 货号 | 产品名 | Cas | 产品描述 |
|---|---|---|---|
| PL01725 | Cavosonstat | 1371587-51-7 | Cavosonstat (N91115) 是一种具有口服活性的 S-nitrosoglutathione reductase (GSNOR) 抑制剂。Cavosonstat 是一种 CFTR 稳定剂，可用于囊性纤维化研究。 |
| PL04312 | N6022 | 1208315-24-5 | N6022 是一种有效的，选择性的，可逆的 S-Nitrosoglutathione reductase (GSNOR) 抑制剂，IC50 值为 8 nM。 |
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