Tim3 is an immunoglobulin type protein expressed exclusively on the surface of differentiated Th1 cells. It is a co-inhibitory receptor immune checkpoint protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
货号 | 产品名 | Cas | 产品描述 |
---|---|---|---|
PL11916 | Sabatolimab | 2252262-24-9 | Sabatolimab (MBG453) 是一种高亲和力的人源化 IgG4 (S228P) 抗体,靶向 TIM-3,一种调节适应性和先天免疫反应的抑制性受体。Sabatolimab 是一种潜在的免疫抑制药物,可以靶向免疫细胞和骨髓细胞上的 TIM-3。 |
PL11915 | TIM-3-IN-1 | TIM-3-IN-1 代表了进一步研究癌症中 TIM-3 免疫调节生物学的有用工具。 |