Dynamin

Dynamins are large superfamily GTPase proteins that are involved in various cellular processes including budding of transport vesicles, division of organelles, cytokinesis, and pathogen resistance. Dynamins are involved in scission (cleavage of the vesicle from the parent membrane) of nascent vesicles from parent membranes in eukaryotic cells. Dynamins interact directly with the lipid bilayer at the necks of clathrin-coated pits to sever and release coated vesicles. Dynamins contain five domains, including GTPase domain, middle domain, PH domain, GTPase effector domain (GED), and proline rich domain (PRD), while the dynamin-related proteins (DRPs) lack one or more of these domains or have additional domains. Dynamins and DRPs participate in a wide variety of cellular processes, including budding mitochondrial fission (mammalian Dlp1 and Saccharomyces cerevisiae Dnm1) and fusion (mammalian OPA1, S.cerevisiae Mgm1 and Schizosaccharomycespombe Msp1), vacuolar fission (S. cerevisiae Vps1), interferon-induced anti-viral protection (fish Mx proteins), plant cell cytokinesis and membrane fission (Arabidopsis thalianaDRP proteins), as well as pathogen resistance.

Dynamin 相关产品（4）

货号	产品名	Cas	产品描述
PL02744	Drp1-IN-1	2247733-08-8	Drp1-IN-1 (comp A-7) 是Drp1 蛋白的抑制剂，其IC50 值为0.91 μM。
PL05841	DynaMin inhibitory peptide, myristoylated	251634-22-7	DynaMin inhibitory peptide, myristoylated 是一种 DynaMin 抑制剂，可干扰两性霉素 (amphiphysin) 与动力蛋白 (dynamin) 的结合。DynaMin inhibitory peptide, myristoylated 是肽的膜渗透形式，可防止细胞内吞。
PL03243	Dynapyrazole-A	2226517-75-3	Dynapyrazole A 是一种特异性的微管动力蛋白抑制剂，可特异性抑制微管刺激的动力蛋白的 ATP 酶活性，但不会阻断微管独立的基础活性。
PL04056	Dynole 2−24	1416313-72-8	Dynole 2−24 是一种基于吲哚的 dynamin GTPase 抑制剂 (对 dynamin I的IC50=0.56 μM)。Dynole 2−24 无毒，在体外和细胞内显示出增强的抗动力蛋白I和II的效力 (IC₅₀(CME)=1.9 μM)。Dynole 2−24 对 dynamin I的选择性为4.4倍。Dynole 2−24在网格蛋白介导的内吞作用的细胞抑制剂中具有活性。CME: Clathrin mediated endocytosis