Ferroportin is a membrane protein belonging to the major facilitator superfamily of transporters. Ferroportin emerges as a critical transporter in terms of iron acquisition and transfer of iron between cell types, as it is the only known transporter that exports elemental iron from cells. Ferroportin is essential to distribute iron between tissues and for iron absorption into the organism. It is inferred that the substrate for ferroportin is Fe(II), based on the observation that iron transport requires an extracellular ferroxidase activity. This ferroxidase is provided by the multicopper oxidases ceruloplasmin (Cp) and/or hephaestin. Several ferroportin mutations lead to the so-called ferroportin disease or type 4 hemochromatosis, characterized by two distinct iron accumulation phenotypes depending on whether the mutation affects the activity of the protein or its degradation pathway.
| 货号 | 产品名 | Cas | 产品描述 |
|---|---|---|---|
| PL02019 | VIT-2763 | 2095668-10-1 | VIT-2763 是具有口服活性的铁转运蛋白 (ferroportin) 的抑制剂，抑制hepcidin 与铁转运蛋白结合，阻滞铁外流。VIT-2763有用于地中海贫血症的潜力。 |
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