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PDI

PDI (蛋白质二硫化物异构酶) 是一种分子量为 55-kDa 的蛋白质,由四个结构域组成,即 a、b、b'、a'。PDI 是内质网 (ER) 中一种丰富的酶。PDI,一种原型硫醇异构酶,是一种重要的氧化酶、还原酶、异构酶和分子伴侣。它可以区分部分折叠、未折叠和正确折叠的蛋白质底物,并在 ER 中的蛋白质折叠过程中催化硫醇-二硫键的形成和裂解。PDI 还可以维持胶原蛋白脯氨酰 4-羟化酶 β 亚基的活性构象,以及维持主要组织相容性复合体 (MHC) 1 类肽加载复合体 (PLC) 的稳定性。PDI 的表达在特定类型的癌症中上调[1][2][3]

PDI (Protein disulfide isomerases) is a 55-kDa protein and consists of four domains namely a, b, b', a'. PDI is an abundant enzyme in the endoplasmic reticulum (ER). PDI, a prototypic thiol isomerase, is an important oxidase, reductase, isomerase and molecular chaperone. It can distinguish between partially folded, unfolded, and properly folded protein substrates, and catalyze the formation and cleavage of thiol-disulfide bonds during protein folding in the ER. PDI can also maintain active conformation of the β subunit of collagen prolyl 4-hydroxylase and stabilization of the major histocompatibility complex's (MHC) class 1 peptide loading complex (PLC). PDI expression is up-regulated in select types of cancers[1][2].

参考文献:

  • [1]. Xu S, et al. Protein disulfide isomerase: a promising target for cancer therapy. Drug Discov Today. 2014 Mar;19(3):222-40

 

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