SGLTs (Sodium-dependent glucose cotransporters) are a family of glucose transporters and contribute to glucose reabsorption. The two most well-known members of SGLT family are SGLT1 and SGLT2, which are members of the SLC5A gene family. The two transporters are of primary importance for glucose homeostasis by absorbing glucose from the diet in the small intestine (via SGLT1) and by reabsorbing the filtered glucose in the tubular system of the kidney (primarily SGLT2; to smaller extent via SGLT1); the latter process returns glucose into the blood stream and prevents urinary glucose loss. SGLT1 and SGLT2 have been proposed as a novel therapeutic strategy for diabetes and cardiomyopathy.
| 货号 | 产品名 | Cas | 产品描述 |
|---|---|---|---|
| PC12776 | fluoro-Dapagliflozin | 1181681-43-5 | 选择性钠-葡萄糖转运蛋白（SGLT）抑制剂，Ki: 5.3 and 330 nM for SGLT2 and SGLT1, respectively，fluoro-Dapagliflozin is a selective sodium-glucose cotransporter (SGLT) inhibitor. |
| PC12781 | galacto-Dapagliflozin | 1408245-02-2 | 人SGLT2的有效抑制剂，Ki = 2 nM，galacto-Dapagliflozin is a potent inhibitor of human SGLT2. |
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