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2-Deoxy-D-glucose.

醣酵解的抑制剂，2-Deoxy-D-glucose 是一种葡萄糖类似物，为葡萄糖代谢抑制剂，通过作用于己糖激酶 (hexokinase) 来抑制糖酵解。

目录号: PC14899 纯度: ≥98%

CAS No. :154-17-6

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PC14899-1g	1g	¥480.00	请登录
PC14899-5g	5g	¥1860.00	请登录
PC14899-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥660.00	请登录

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中文名称

2-Deoxy-D-glucose.

中文别名

2-脱氧葡萄糖;2-脱氧-D-葡萄糖;2-去氧-D-葡萄糖;D-2-脱氧葡萄糖;2-Deoxy-D-glucose 2-脱氧-D-葡萄糖;2-脫氧-D-葡萄糖;2-脱氧-D葡萄糖;2-脱氧葡萄糖原药;D-2-脱氧葡萄糖 USP标准品;夫西地酸;脱氧葡萄糖;2-去氧-D-葡糖;2-去氧-D-葡萄糖,D-2-脱氧葡萄糖;2-脱氧-D-葡糖;D-2-脱氧葡萄;抗感染药;玫瑰红银试剂;去氧葡萄糖;D-2-脱氧葡萄糖 1G;2-去氧-D-葡萄糖,98%

英文名称

2-Deoxy-D-Glucose

英文别名

2-Deoxy-D-Glucose;2-deoxy-D-glucose, mixture of anomers;2-deoxy-D-glucose sigmaultra;2-deoxy-D-glucose grade iii;2-deoxy-D-glucose grade ii;2-Deoxy-D-Arabino;2-DEOXY-D-ARABINOHEXOSE;2-Deoxy-D-glucose (2-DG,NSC 15193,Ba 2758);DEOXY-D-GLUCOSE, 2-(RG);2-deoxy-d-arabino-hexos;2-Deoxy-D-arabino-hexose;D-Arabino-2-deoxyhexose;p-DiMethylaMinobenzalrhodanine;2-Deoxyglucose;2-dg;ba2758;D-2dGlc;nsc15193;deoxyglucose;2-deoxy-glucos;2-DEOXYGLUCOSE;D-2-GLUCODESOSE;d-2-deoxyglucose;2-deoxy-d-glucos

Cas No.

154-17-6

分子式

C₆H₁₂O₅

分子量

164.16

包装储存

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

生物活性

2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.

性状

Solid

IC50 & Target[1][2]

HSV-1

体外研究(In Vitro)

2-Deoxy-D-glucose (2-DG, 4, 8, or 16 mM) significantly reduces the level of ATP in MCF-7 cells in a dose- and time-dependent manner that paralleles the effects of 2-DG on cell growth. The levels of phosphorylated Akt are significantly decreased, whereas the levels of phosphorylated AMPK and Sirt-1 are significantly increased in MCF-7 cells exposed to 2-Deoxy-D-glucose at 4, 8, or 16 mM for 1, 3, or 5 days in a dose- and time-dependent manner. 2-DG treatment increases the levels of pentose phosphate pathway (PPP) metabolites and augments the generation of NADPH by glucose-6-phosphate dehydrogenase. An increase in NADPH and upregulation of glutathione synthetase expression resultes in the increase in the reduced form of glutathione by 2-DG in NB4 cells.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

2-Deoxy-D-glucose (0.03%, w/w) causes a 7% decrease in final weight that is statistically significant, and delayes the appearance of palpable mammary carcinomas. 2-Deoxy-D-glucose (3 mmol/kg, i.v.) is decreased in a dose-dependent manner in rat muscle.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transportation.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

ClinicalTrial

结构分类

参考文献

[1]. Zhu Z, et al. 2-Deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth 体外研究. Cancer Res. 2005 Aug 1;65(15):7023-30. [Information]

[2]. Ueyama A, et al. Nonradioisotope assay of glucose uptake activity in rat skeletal muscle using enzymatic measurement of 2-deoxyglucose 6-phosphate 体外研究 and in vivo. Biol Signals Recept. 2000 Sep-Oct;9(5):267-74. [Information]

[3]. Miwa H, et al. Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose. Oncol Rep. 2013 May;29(5):2053-7. [Information]

溶解度数据

体外研究:

H₂O : ≥ 24 mg/mL (146.20 mM)

* "≥" means soluble, but saturation unknown.

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	6.0916 mL	30.4581 mL	60.9162 mL
5 mM	1.2183 mL	6.0916 mL	12.1832 mL
10 mM	0.6092 mL	3.0458 mL	6.0916 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 130 mg/mL (791.91 mM); Clear solution; Need ultrasonic

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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