Tauro-β-muricholic acid sodium|145022-92-0|(T-βMCA sodium)-陌孚医药/Medlife

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Tauro-β-muricholic acid sodium (Synonyms: T-βMCA sodium)

目录号: PL03439 纯度: ≥95%

CAS No. :145022-92-0

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中文名称	Tauro-β-muricholic acid sodium
英文名称	Tauro-β-muricholic acid sodium
英文别名	Tauro-β-muricholic acid sodium;Tauro-;A-muricholic acid sodium salt;Tauro-\|A-muricholic acid sodium salt
Cas No.	145022-92-0
分子式	C₂₆H₄₄NNaO₇S
分子量	537.68
包装储存	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情	Tauro-β-muricholic Acid sodium (T-βMCA sodium) 是一种内源性代谢物，是一种竞争性、可逆的 FXR 拮抗剂，其 IC₅₀ 值为 40 μM。
生物活性	Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC 50 of 40 μM.
性状	Solid
IC50 & Target[1][2]	IC50: 40 μM (FXR)
体外研究(In Vitro)	T-βMCA sodium inhibits FXR reporter activity in the CRC cell line HT29 (EC50 ~10 μM). T-βMCA sodium dose-dependently increases WNT signaling in HT29 and HCT116 cells. T-βMCA sodium induces proliferation and DNA damage in Lgr5 cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression. T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Sayin SI, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013 Feb 5;17(2):225-35. [2]. Wahlstr?m A, et al. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota. J Lipid Res. 2017 Feb;58(2):412-419.

溶解度数据	In Vitro: DMSO : 10 mg/mL (18.60 mM; Need ultrasonic and warming)配制储备液

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