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L48H37

目录号: PL12299 纯度: ≥97%

L48H37 是一种化学稳定性提高了的姜黄素 (HY-N0005) 类似物。L48H37 是一种有效且特异性的髓系分化蛋白 2 (MD2) 抑制剂，抑制 LPS-TLR4/MD2 的相互作用和信号转导。L48H37 用于脓毒症或肺损伤的相关研究。

CAS No. :343307-76-6

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PL12299-500mg	500mg	询价	询价

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中文名称	L48H37
英文名称	L48H37
英文别名	4-Piperidinone, 1-ethyl-3,5-bis[(3,4,5-trimethoxyphenyl)methylene]-;1-ethyl-3,5-bis[(3,4,5-trimethoxyphenyl)methylidene]piperidin-4-one;L48H37
Cas No.	343307-76-6
分子式	C₂₇H₃₃NO₇
分子量	483.55
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
详情描述	L48H37 是一种化学稳定性提高了的姜黄素 (HY-N0005) 类似物。L48H37 是一种有效且特异性的髓系分化蛋白 2 (MD2) 抑制剂，抑制 LPS-TLR4/MD2 的相互作用和信号转导。L48H37 用于脓毒症或肺损伤的相关研究。

产品详情	L48H37 是一种化学稳定性提高了的姜黄素 (HY-N0005) 类似物。L48H37 是一种有效且特异性的髓系分化蛋白 2 (MD2) 抑制剂，抑制 LPS-TLR4/MD2 的相互作用和信号转导。L48H37 用于脓毒症或肺损伤的相关研究。
生物活性	L48H37 is an analog of Curcumin (HY-N0005) with improved chemical stability. L48H37 is a potent and specific myeloid differentiation protein 2 (MD2) inhibitor and inhibits the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is used for the research of sepsis or lung injury treatment.
性状	Solid
IC50 & Target[1][2]	TLR4
体外研究(In Vitro)	L48H37 inhibits LPS-induced inflammation, particularly TNF-α and IL-6 production and gene expression in mouse macrophages. L48H37 (0-20?μM; 24 hours) decreases the viability of A549 and H460 cells with IC50 values of 5.3?μM and 2.3?μM, respectively, which is more effective compared to curcumin in lung cancer cells. It shows a low cytotoxicity on normal human lung epithelial cells (BEAS-2B) with IC50 of 21?μM. L48H37 (1, 2, or 4?μM; 16 hours) dose‐dependently inhibited the expression of p‐Cdc2 and Cdc2, and increases the expression of p53. It also shows increased levels of cleaved poly (ADP‐ribosyl) polymerase (PARP) and reduced levels of anti‐apoptotic protein Bcl‐2 in H460 and A549 cells. L48H37 (4?μM; 16?hours) rapidly induces intracellular ROS levels dose-dependently as detected by increased DCF levels in H460 and A549 cells.
体内研究(In Vivo)	L48H37 (intraperitoneal injection; 5?mg or 10?mg/kg; once daily; 11‐day ) inhibits H460 xenograft tumor growth and exhibits anti‐tumor activity in mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Yi Wang, et al. Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2. J Pharmacol Exp Ther. 2015 Jun;353(3):539-50 [2]. Chen Feng, et al. Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells. Mol Carcinog. 2017 Jul;56(7):1765-1777.

溶解度数据	In Vitro: DMSO : 50 mg/mL (103.40 mM; Need ultrasonic)配制储备液

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[1]. Yi Wang, et al. Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2. J Pharmacol Exp Ther. 2015 Jun;353(3):539-50
[2]. Chen Feng, et al. Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells. Mol Carcinog. 2017 Jul;56(7):1765-1777.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

L48H37

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