Pepinh-TRIF TFA
目录号: PL12333 纯度: ≥99%
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中文名称
Pepinh-TRIF TFA
英文名称
Pepinh-TRIF TFA
包装储存
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
产品详情
Pepinh-TRIF (TFA) 是一种 30 aa 肽,通过干扰 TLR-TRIF 的相互作用 (TLR-TRIF interaction ) 来阻断 TRIF 信号。
生物活性
Pepinh-TRIF (TFA) is a 30 aa peptide that blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction.
性状
Solid
体外研究(In Vitro)
Pepinh-TRIF (40 μM, 6 hours) blocks the expression and production of IL-33 stimulated by polyI:C or flagellin, and also greatly suppresses the stimulated IκB-α phosphorylation and degradation in HCECs.
Pepinh-TRIF (40 μM, 6 hours) suppresses NF-κB activation with p65 protein nuclear translocation .
has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years;-20°C 1 ye
SequenceShortening
RQIKIWFQNRRMKWKKFCEEFQVPGRGELH-NH2
参考文献
[1]. Amal Hasan, et al. TNF-α in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation. Int J Mol Sci. 2019 Aug 23;20(17):4112.
溶解度数据
In Vitro: H2O : 50 mg/mL (12.45 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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