SM-324405|677773-91-0|-陌孚医药/Medlife

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SM-324405

目录号: PL12289 纯度: ≥98%

CAS No. :677773-91-0

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中文名称	SM-324405
中文别名	2-(3-((6-氨基-2-丁氧基-8-氧代-7H-嘌呤-9(8H)-基)甲基)苯基)乙酸甲酯
英文名称	SM-324405
英文别名	SM 324405;Methyl 3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]benzeneacetate;methyl 2-[3-[(6-amino-2-butoxy-8-oxo-7H-purin-9-yl)methyl]phenyl]acetate;BDBM50315256;Methyl{3-[(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)methyl]phenyl}acetate;Methyl3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]benzeneacetate;SM-324405
Cas No.	677773-91-0
分子式	C₁₉H₂₃N₅O₄
分子量	385.42
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	SM-324405 是 TLR7 的激动剂 (EC₅₀ = 50 nM)，其对人和大鼠 TLR7 的 pEC₅₀ 值分别为 7.3 和 6.6。SM-324405 用于过敏性疾病的免疫治疗研究。Antedrug 被定义为一种局部活性化合物，在进入循环后迅速代谢为非活性形式，并通过在血浆环境中失去激动活性来防止全身毒性。
生物活性	SM-324405 is a TLR7 agonistic antedrug (EC 50 = 50 nM), with pEC 50 values of 7.3 and 6.6 for human TLR7 and Rat TLR7, respectively. SM-324405 is used for immunotherapy of allergic diseases. An antedrug is defined as a locally active compound that is designed to be rapidly metabolized to an inactive form upon entry into the circulation and prevents systemic toxicity by losing its agonistic activity in a plasmatic environment.
性状	Solid
IC50 & Target[1][2]	TLR7 50 nM (EC50) human TLR7 7.3 (pEC
体外研究(In Vitro)	SM-324405 is a novel candidate for immunotherapy of allergic diseases. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	SM-324405 (9e, intratracheal administration) effectively inhibits allergen-induced airway inflammation without inducing cytokines systemically. SM-324405 is metabolized to the corresponding acid in human plasma with t 1/2 of 2.6 min. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Ayumu Kurimoto, et al. Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. J Med Chem. 2010 Apr 8;53(7):2964-72. [2]. M Biffen, et al. Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. Br J Pharmacol. 2012 May;166(2):573-86.

溶解度数据	In Vitro: DMSO : 50 mg/mL (129.73 mM; Need ultrasonic)配制储备液

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