GSK2245035|1207629-49-9|-陌孚医药/Medlife

您当前的位置：

GSK2245035

目录号: PL11941 纯度: ≥99%

CAS No. :1207629-49-9

商品编号	规格	价格	会员价
PL11941-5mg	5mg	¥4821.00	请登录
PL11941-10mg	10mg	¥7714.00	请登录
PL11941-50mg	50mg	¥21698.00	请登录
PL11941-100mg	100mg	¥28930.00	请登录
PL11941-200mg	200mg	询价	询价
PL11941-500mg	500mg	询价	询价
PL11941-10mM*1mLinDMSO	10mM*1mLinDMSO	¥5304.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	GSK2245035
英文名称	GSK2245035
英文别名	GSK2245035;5L3SX16QBQ;GTPL9254;LFMPVTVPXHNXOT-HNNXBMFYSA-N;SB19815;compound 32 [PMID: 26861551];J3.609.218A;(S)-6-amino-2-(pentan-2-yloxy)-9-(5-(piperidin-1-yl)pentyl)-7,9-dihydro-8H-purin-8-one;6-amino-2-[(2S)-pentan-2-yloxy]-9-[5-(piperidin-1-yl)pentyl]-8,9-dihydro-7H-purin-8-one;6-amino-2-{[(1S)-1-methylbutyl]oxy}-9[5-(1-piperidinyl) pentyl]-7,9-dihydro-8H-purin-8-one;8H-Purin-8-one, 6-amino-7;8H-Purin-8-one, 6-amino-7,9-dihydro-2-((1S)-1-methylbutoxy)-9-(5-(1-piperidinyl)pentyl)-
Cas No.	1207629-49-9
分子式	C₂₀H₃₄N₆O₂
分子量	390.52
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

GSK2245035 是一种高效的，选择性的鼻内 Toll-Like 受体 7 (TLR7) 激动剂，具有优先刺激 1 型干扰素 (IFN) 的特性。GSK2245035 对 IFNα 和TNFα 的 pEC₅₀ 分别为 9.3 和 6.5。GSK2245035 有效抑制人外周血细胞培养物中过敏原诱导的 Th2 细胞因子产生。GSK2245035 有用于哮喘的潜力。

生物活性

GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC 50 s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma.

性状

Solid

IC50 & Target[1][2]

TLR7 IFNα 9.3 (pEC50)

体外研究(In Vitro)

GSK2245035 (0.01, 0.1, 1, 10, 100, 1000, 10000 nM; 6 days) reduces levels of the Th2 cytokines IL-5 and IL-13 released in response to Timothy grass or house dust mite in human PBMC cultures derived from individuals allergic to these allergens, in a dose-dependent manner.
has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

GSK2245035 (i.n.; 0.03-1 mg/kg; 6 hours) makes dose-related increasing in IFNα levels in serum at doses of 0.3 mg/kg and above at the 2 h time point which had subsided at 6 h.
GSK2245035 (3, 30, 300, 3000 ng/kg; 6 hours) treatment can make plasma IP-10 provided the most sensitive biomarker of target engagement with raised levels of this chemokine detected at doses of 30 ng/kg and above in the cynomolgus monkey.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Biggadike K, et al. Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma. J Med Chem. 2016 M

溶解度数据	In Vitro: DMSO : 125 mg/mL (320.09 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation