CU CPT 4a;(R)-2-(3-chloro-6-fluorobenzo[b]thiophene-2-carboxamido)-3-phenylpropanoic acid;CUCPT4a;IAASQMCXDRISAV-CYBMUJFWSA-N;N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine;N-[(3-Chloro-6-fluorobenzo[b]thiophene-2-yl)carbonyl]-D-phenylalanine
Cas No.
1279713-77-7
分子式
C18NO3FSclH13
分子量
377.82
包装储存
Powder
-20°C
3 years
4°C
2 years
In solvent
-80°C
6 months
-20°C
1 month
生物活性
CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β.
性状
Solid
IC50 & Target[1][2]
TLR3
3.44 μM (IC50, in RAW 264.7 cells)
体外研究(In Vitro)
CU-CPT 4a shows dose-dependent inhibitory effects blocking Poly (I:C)-induced TLR3 activation with an IC50 of 3.44 μM.
CU-CPT 4a competes with dsRNA for binding to TLR3 with a Ki of 2.96 μM.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.