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27-Hydroxycholesterol

(Synonyms: 27-羟基胆固醇; 27-OHC)

目录号: PC61706 纯度: ≥99%

27-Hydroxycholesterol是选择性的雌激素受体 (estrogen receptor) 调节剂和肝X 受体 (liver X receptor) 激动剂。27-Hydroxycholesterol是选择性的雌激素受体 (estrogen receptor) 调节剂和肝X 受体 (liver X receptor) 激动剂。

CAS No. :20380-11-4

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中文名称	27-Hydroxycholesterol
中文别名	27-羟基胆固醇;[2H] -5,25 R-胆甾烯3.beta . ,26-二醇标准品;5,25R-胆甾烯-3BETA,26-二醇
英文名称	27-Hydroxycholesterol
英文别名	27-Hydroxycholesterol;cholest-(25R)-5-ene-3β,27-diol;(25R)-26-Hydroxycholesterol;25(R)-27-hydroxy Cholesterol;5,25R-Cholesten-3beta,26-diol;cholest-(25R)-5-ene-3ß,27-diol;(25R)-cholest-5-ene-3beta,26-diol;(25R)-26-Hydroxycholesterol;(25R)-Cholest-5-ene-3b,26-diol;27-OHC;110818;27-hydroxycholesterol(25R);cholest-5-ene-3β,27-diol, (25R);(3R,8R,9R,10S,13S,14R,17S)-17-[(2S)-7-Hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,;6T2NA6P5SQ
Cas No.	20380-11-4
分子式	C₂₇H₄₆O₂
分子量	402.65
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；
详情描述	27-Hydroxycholesterol是选择性的雌激素受体 (estrogen receptor) 调节剂和肝X 受体 (liver X receptor) 激动剂。27-Hydroxycholesterol是选择性的雌激素受体 (estrogen receptor) 调节剂和肝X 受体 (liver X receptor) 激动剂。

生物活性	27-Hydroxycholesterol is a selective estrogen receptor modulator and an agonist of the liver X receptor.
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite

体外研究(In Vitro)

27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer. 27-Hydroxycholesterol, through estrogen receptor activation, triggers deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol also acts as an endogenous selective estrogen receptor modulator capable of increasing breast cancer growth and metastasis. 27-Hydroxycholesterol

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

结构分类

Others