您当前的位置：

Compound 48/80 trihydrochloride

(Synonyms: C48/80 trihydrochloride)

目录号: PL09423 纯度: ≥99%

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺与甲醛缩合产物的混合物。Compound 48/80 trihydrochloride 也是一种组胺 (histamine) 释放剂和肥大细胞 (mast cell) 脱颗粒剂。Compound 48/80 trihydrochloride 抑制人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性。

CAS No. :848035-21-2

商品编号	规格	价格	会员价
PL09423-50mg	50mg	¥1768.00	请登录
PL09423-100mg	100mg	¥3053.00	请登录
PL09423-200mg	200mg	询价	询价
PL09423-500mg	500mg	询价	询价
PL09423-1 mL x 10 mM (in DMSO)	1 mL x 10 mM (in DMSO)	¥94.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

*注意事项:下单时请联系销售核实产品价格及货期，避免后续产生不便，感谢支持!

加入购物车在线咨询收藏产品大包装询价

中文名称	Compound 48/80 trihydrochloride
中文别名	化合物 T13623
英文名称	Compound 48/80 trihydrochloride
英文别名	Compound 48/80 (hydrochloride);Compound 48/80 (trihydrochloride);2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-N-methylethanamine;trihydrochloride;4-methoxy-3,5-bis[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-N-methyl-benzeneethanamine,trihydrochloride;Compound 48/80 hydrochloride;C48/80 trihydrochloride;Compound 48/80 trihydrochloride
Cas No.	848035-21-2
分子式	C₃₂H₄₈Cl₃N₃O₃
分子量	629.10
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺与甲醛缩合产物的混合物。Compound 48/80 trihydrochloride 也是一种组胺 (histamine) 释放剂和肥大细胞 (mast cell) 脱颗粒剂。Compound 48/80 trihydrochloride 抑制人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性。

产品详情	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺与甲醛缩合产物的混合物。Compound 48/80 trihydrochloride 也是一种组胺 (histamine) 释放剂和肥大细胞 (mast cell) 脱颗粒剂。Compound 48/80 trihydrochloride 抑制人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性。
生物活性	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .
性状	Solid
体外研究(In Vitro)	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC50 values are 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter. Compound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Bronner C, et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys Acta. 1987 Aug 15;920(3):301-5. [2]. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104.

溶解度数据	In Vitro: H₂O : 25 mg/mL (39.74 mM; Need ultrasonic)DMSO : 10 mg/mL (15.90 mM; ultrasonic and warming and heat to 60°C)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

[1]. Bronner C, et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys Acta. 1987 Aug 15;920(3):301-5.
[2]. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Compound 48/80 trihydrochloride

相关产品

The molarity calculator equation

The dilution calculator equation