Mepivacaine|96-88-8|-陌孚医药/Medlife

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Mepivacaine

目录号: PL11357 纯度: ≥98.0%

CAS No. :96-88-8

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中文名称	Mepivacaine
中文别名	2-甲基-2,6-壬二烯-1-胺;N-(2,6-二甲基苯基)-1-甲基哌啶-2-羧酰胺;甲哌卡因;N-(2,6-二甲基苯基)-1-甲基-2-哌啶甲酰胺盐酸盐;盐酸甲哌卡因(MEPIVACAINEHCL)中间体
英文名称	Mepivacaine
英文别名	N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide;2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-1-methyl-;Mepivacaine;Carbocaine;DL-Mepivacaine;Scandicain;Scandicaine;Mepivacaina;Mepivacainum;Mepicaine;Polocaine;Mepivicaine;Mepivacainum [INN-Latin];Mepivacaina [INN-Spanish];(+-)-1-Methyl-2',6'-pipecoloxylidide;Mepivacaine [INN:BAN];N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide;1-METHYL-2',6'-PIPECOLOXYLIDIDE;2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-;N-Methyl-2-pipecolic acid, 2,6-xylidide;2',6'-Pipec;2′,6′-Pipecoloxylidide, 1-methyl- (6CI, 8CI);N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide (ACI);(±)-Mepivacaine;1-Methyl-2′,6′-pipecoloxylidide;DL;APF 135;Carbocain;Carbocaine-V;MepiSV;MeSH ID: D008619;Scandinibsa;Tevacaine
Cas No.	96-88-8
分子式	C₁₅H₂₂N₂O
分子量	246.35
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Mepivacaine 是一种酰胺型药剂，可暂时使局部失去知觉。Mepivacaine 与神经元细胞膜上特定的电压门控钠离子通道结合，抑制钠离子内流和膜去极化。

生物活性

Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.

性状

Solid

体外研究(In Vitro)

Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action.
Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine).
Mepivacaine displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Froehle M, et al. ECMO for Cardiac Rescue after Accidental Intravenous Mepivacaine Application. Case Rep Pediatr. 2012;2012:491692.
[2]. mepivacaine hydrochloride.
[3]. Burm, A.G., et al., Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers. Anesth Analg, 1997. 84(1): p. 85-9.

溶解度数据	In Vitro: DMSO : 33.33 mg/mL (135.30 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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