QX-314 chloride|5369-03-9|-陌孚医药/Medlife

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QX-314 chloride

目录号: PL11385 纯度: ≥99%

CAS No. :5369-03-9

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中文名称	QX-314 chloride
英文名称	QX-314 chloride
英文别名	Ethanaminium,2-[(2,6-dimethylphenyl)amino]-N,N,N-triethyl-2-oxo-, chloride (1:1);N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE;QX 314 chloride;lidocaine ethochloride;Lidocaine N-ethyl chloride;QX-314 chloride
Cas No.	5369-03-9
分子式	C₁₆H₂₇N₂O+^.Cl-
分子量	298.85
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	QX-314 chloride 是一种膜不渗透的钠离子通道永久性电荷阻滞剂。
生物活性	QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker.
性状	Solid
IC50 & Target[1][2]	sodium channel
体外研究(In Vitro)	QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro. QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner. QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca currents are on average < 45% of control amplitude. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114(6):1425-34. [2]. Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76(3):2120-4.

溶解度数据	In Vitro: H₂O : 50 mg/mL (167.31 mM; Need ultrasonic)DMSO : 14.29 mg/mL (47.82 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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