PF-06305591 dihydrate||-陌孚医药/Medlife

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PF-06305591 dihydrate

目录号: PL11352 纯度: ≥99.0%

商品编号	规格	价格	会员价
PL11352-5mg	5mg	¥4821.00	请登录
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PL11352-50mg	50mg	询价	询价
PL11352-10mM*1mLinDMSO	10mM*1mLinDMSO	¥5304.00	请登录

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中文名称	PF-06305591 dihydrate
英文名称	PF-06305591 dihydrate
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情

PF-06305591 dihydrate 是一种有效的、高选择性的电压门控钠通道 NaV1.8 的阻断剂，其IC₅₀ 值为15 nM。具有良好的临床前体外ADME (吸收、分布、代谢和排泄) 和安全性。

生物活性

PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC 50 of 15 nM. An excellent preclinical in vitro ADME and safety profile.

性状

Solid

IC50 & Target[1][2]

Nav1.8 1.5 nM (IC50)

体外研究(In Vitro)

PF-06305591 (compound 9) has a highly attractive profile with respect to NaV selectivity, hERG activity, passive permeability and in vitro metabolic stability. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

PF-06305591 (compound 9) has good rat bioavailability. PF-06305591 offers the possibility of investigating higher IC 50 multiples of Nav1.8 blockade in the clinic, and therefore a more thorough evaluation of the role of NaV1.8 in the treatment of pain. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；In solvent -80°C 6 months

ClinicalTrial

参考文献

[1]. Brown AD, et al. The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain. Bioorg Med Chem. 2019 Jan 1;27(1):230-239.

溶解度数据	In Vitro: DMSO : 100 mg/mL (322.18 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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