Flecainide-d4 (acetate)|1276197-21-7|-陌孚医药/Medlife

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Flecainide-d4 (acetate)

目录号: PL11329 纯度: ≥99.0%

CAS No. :1276197-21-7

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中文名称	Flecainide-d4 (acetate)
中文别名	醋酸洗必太-D4氘代内标;醋酸洗必太-D4;氟卡胺-d4醋酸盐[双(2,2,2-三氟代乙氧基-1,1-d2)];氟卡尼 D4醋酸盐;醋酸氟卡尼 d4 (醋酸盐)
英文名称	Flecainide-d4 (acetate)
英文别名	Flecainide-d4?Acetate [bis(2,2,2-trifluoroethoxy-1,1-d2)];Flecainide-d4 Acetate [bis(2,2,2-trifluoroethoxy-1,1-d2)];Flecainide-d4 Acetate [bis(2,2,2-trifluoroethoxy-2,2-d2);Flecainide D4 acetateQ: What is Flecainide D4 acetate Q: What is the CAS Number of Flecainide D4 acetate Q: What is the storage condition of Flecainide D4 acetate Q: What are the applications of Flecainide D4 acetate;Flecainide-d4 (acetate);Flecainide-d4 Acetate bis(2,2,2-trifluoroethoxy-2,2-d2)
Cas No.	1276197-21-7
分子式	C₁₉H₂₄F₆N₂O₅
分子量	474.39
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Flecainide-d₄ (acetate) 是 Flecainide acetate 的氘代物。Flecainide acetate (R-818) 能阻断位于心脏的 Nav1.5钠离子通道，能抗心律失常。
生物活性	Flecainide-d 4 (acetate) is the deuterium labeled Flecainide acetate. Flecainide acetate (R-818) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential[1][2].
性状	Solid
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Yamashita T, Nakajima T, Hamada E, Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart. J Pharmacol Exp Ther. 1995 Jul;274(1):315-21.

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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