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Dibucaine hydrochloride

目录号: PL11376 纯度: ≥99%

Dibucaine hydrochloride (Cinchocaine hydrochloride) 是一种钠通道抑制剂。 Dibucaine hydrochloride 是有效的 SChE 抑制剂。

CAS No. :61-12-1

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中文名称	Dibucaine hydrochloride
中文别名	盐酸地布卡因;盐酸辛可卡因;2-丁氧基-N-(2-二乙氨基乙基)-4-喹啉甲酰胺盐酸盐;狄布卡因盐酸盐;霹雳可卡因;盐酸地布卡因天然可卡因;(R)-巴氯芬;2-丁氧基-N-(2-二乙氨乙基)-4-喹啉甲酰胺盐酸盐;盐酸狄布卡因;盐酸待布卡因
英文名称	Dibucaine hydrochloride
英文别名	Dibucaine hydrochloride;2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide monohydrochloride;2-Butoxy-N-(2-diethylaminoethyl)cinchoninamide hydrochloride;Cinchocaine HCl;Cinchocaine hydrochloride;DIBUCAINE HYDROCHLORIDE CRYSTALLINE;2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide,hydrochloride;CINCHOCAINE HYDROCHLORIDE,USP29;EP5;Nupercaine hydrochloride;Dibucaine HCl;Dibucaine (Cinchocaine) HCl;Cincaine chloride;Dibucaine (hydrochloride);Sovcain;Percaine;Sovcainum;Percain;Percamin S;2-Butoxy-N-(2-(diethylamino)ethyl)quinoline-4-carboxamide hydrochloride;Cincaine hydrochloride;Cinchocainium chloride;MLS000028429;Heavy Solution Nupercaine;Z97702A5DG;Benzolin (local anesthetic);Cinchokain hydrochlorid [Czech];AK326166;SMR000058369;EIN
Cas No.	61-12-1
分子式	C₂₀H₃₀ClN₃O₂
分子量	379.92
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Dibucaine hydrochloride (Cinchocaine hydrochloride) 是一种钠通道抑制剂。 Dibucaine hydrochloride 是有效的 SChE 抑制剂。

产品详情	Dibucaine hydrochloride (Cinchocaine hydrochloride) 是一种钠通道抑制剂。 Dibucaine hydrochloride 是有效的 SChE 抑制剂。
生物活性	Dibucaine hydrochloride (Cinchocaine hydrochloride) is a sodium channel inhibitor. Dibucaine hydrochloride is a potent SChE inhibitor.
性状	Solid
体外研究(In Vitro)	Dibucaine hydrochloride (Cinchocaine hydrochloride) reduced the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain.Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Souto-Padron, T., A.P. Lima, and O. Ribeiro Rde, Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi. Parasitol Res, 2006. 99(4): p. 317-20. [2]. Elamin, B., Dibucaine inhibition of serum cholinesterase. J Biochem Mol Biol, 2003. 36(2): p. 149-53.

溶解度数据	In Vitro: DMSO : 110 mg/mL (289.53 mM; Need ultrasonic)H₂O : 100 mg/mL (263.21 mM; Need ultrasonic)配制储备液

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[1]. Souto-Padron, T., A.P. Lima, and O. Ribeiro Rde, Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi. Parasitol Res, 2006. 99(4): p. 317-20.
[2]. Elamin, B., Dibucaine inhibition of serum cholinesterase. J Biochem Mol Biol, 2003. 36(2): p. 149-53.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Dibucaine hydrochloride

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