Dibucaine hydrochloride|61-12-1|-陌孚医药/Medlife

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Dibucaine hydrochloride

目录号: PL11376 纯度: ≥99%

CAS No. :61-12-1

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中文名称	Dibucaine hydrochloride
中文别名	盐酸地布卡因;盐酸辛可卡因;2-丁氧基-N-(2-二乙氨基乙基)-4-喹啉甲酰胺盐酸盐;狄布卡因盐酸盐;霹雳可卡因;盐酸地布卡因天然可卡因;(R)-巴氯芬;2-丁氧基-N-(2-二乙氨乙基)-4-喹啉甲酰胺盐酸盐;盐酸狄布卡因;盐酸待布卡因
英文名称	Dibucaine hydrochloride
英文别名	Dibucaine hydrochloride;2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide monohydrochloride;2-Butoxy-N-(2-diethylaminoethyl)cinchoninamide hydrochloride;Cinchocaine HCl;Cinchocaine hydrochloride;DIBUCAINE HYDROCHLORIDE CRYSTALLINE;2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide,hydrochloride;CINCHOCAINE HYDROCHLORIDE,USP29;EP5;Nupercaine hydrochloride;Dibucaine HCl;Dibucaine (Cinchocaine) HCl;Cincaine chloride;Dibucaine (hydrochloride);Sovcain;Percaine;Sovcainum;Percain;Percamin S;2-Butoxy-N-(2-(diethylamino)ethyl)quinoline-4-carboxamide hydrochloride;Cincaine hydrochloride;Cinchocainium chloride;MLS000028429;Heavy Solution Nupercaine;Z97702A5DG;Benzolin (local anesthetic);Cinchokain hydrochlorid [Czech];AK326166;SMR000058369;EIN
Cas No.	61-12-1
分子式	C₂₀H₃₀ClN₃O₂
分子量	379.92
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Dibucaine hydrochloride (Cinchocaine hydrochloride) 是一种钠通道抑制剂。 Dibucaine hydrochloride 是有效的 SChE 抑制剂。
生物活性	Dibucaine hydrochloride (Cinchocaine hydrochloride) is a sodium channel inhibitor. Dibucaine hydrochloride is a potent SChE inhibitor.
性状	Solid
体外研究(In Vitro)	Dibucaine hydrochloride (Cinchocaine hydrochloride) reduced the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain.Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Souto-Padron, T., A.P. Lima, and O. Ribeiro Rde, Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi. Parasitol Res, 2006. 99(4): p. 317-20. [2]. Elamin, B., Dibucaine inhibition of serum cholinesterase. J Biochem Mol Biol, 2003. 36(2): p. 149-53.

溶解度数据	In Vitro: DMSO : 110 mg/mL (289.53 mM; Need ultrasonic)H₂O : 100 mg/mL (263.21 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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