Dibucaine|85-79-0|-陌孚医药/Medlife

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Dibucaine

目录号: PL11378 纯度: ≥99%

CAS No. :85-79-0

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中文名称	Dibucaine
中文别名	辛可卡因;地布卡因;2-丁氧基-N-(2-二乙基氨基乙基)喹啉-4-甲酰胺;Cinchocaine (Dibucaine) 辛可（地布）卡因;地布卡因碱基;地步卡因碱基;辛***;盐酸地布卡因;CINCHOCAINE (DIBUCAINE) 辛可(地布)卡因;狄布卡因;地布卡因,Dibucaine,分析标准品;辛可卡因中间体;待布卡因
英文名称	Dibucaine
英文别名	Cinchocaine;2-Butoxy-N-(2-diethylaminoethyl)quinoline-4-carboxamide;2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide;4-Quinolinecarboxamide,2-butoxy-N-[2-(diethylamino)ethyl]-;Cinchocaine(Dibucaine);DIBUCAINE;Cinchocainum;Cincocainio;Dermacaine;Dibucain;Dibucaine Base;dibucaine hydrochloride;Nupercainal;Nupercaine;Sovcaine;Percamine;Cincainum;Dibucainum;Dibucaine [USP];Nupercainal (VAN);Cincocaina [DCIT];Cincain;Cinchocainum [INN-Latin];Cincocainio [INN-Spanish];2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide;2-butoxy-N-(2-(diethylamino)ethyl)quinoline-4-carboxamide;N-(2-(Diethylamino)ethyl)-2-butoxycinchoninamide;2;Spectrum5_000865;MLS000028425;HMS1568O13;D00733;BRN 0275489;Nupercainal (TN);BRD-K99121711-001-03-5;Cinchocaine HCL;2-butoxy-N-(2-diethylaminoethyl)cinchoninamide;HMS3712O13;IDI1_000332;FT-0603086;2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide;Prestwick3_000076;SPBio_001121;MFCD00047595;N-[2-(Diethylamino)ethyl]-2-butoxycinchoninamide;L6JW2TJG99;HMS3370I12;BRD-K99121711-003-12-2;AKOS015897110;Spectrum_000928;CS-O-06228;KBio2_006544;HSDB 3312;85-79-0;CINCHOCAINE [WHO-DD];s5534;NCGC00016338-04;alpha-Butyloxycinchonic acid-gamma-diethylethylenediamine;DIBUCAINE [USP MONOGRAPH];STL483757;BDBM48532;C07879;KBioSS_001408;BSPBio_002167;2-Butoxy-N-(.beta.-diethylaminoethyl)cinchoninamide;InChI=1/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24;SY107339;QUINOLINE,2-BUTOXY,4-CARBOXY,(N-TRIETHYLAMINO) AMIDE CINCHOCAIN;WLN: T66 BNJ CO4 EVM2N2&2;D0P5GE;alpha-Butyloxycinchoninic acid diethylethylenediamide;Prestwick0_000076;AC-2093;EINECS 201-632-1;MLS001148085;2-Butoxy-N-(2-(diethylamino)ethyl)cinchoninamide;SBI-0051340.P003;KBio1_000332;AB00053453;cinchocain-;HMS2233F03;CAS-85-79-0;2-Butoxy-N-[2-(diethylamino)ethyl]cinchoninamide;DivK1c_000332;NCGC00016338-03;SR-01000003037-6;cid_521951;2-N-Butoxy-N-(2-diethylaminoethyl)cinchoninamide;Opera_ID_192;NCGC00016338-05;Prestwick2_000076;SCHEMBL34473;NCGC00016338-07;2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide;hydrochloride;DB00527;DIBUCAINE [VANDF];4-Quinolinecarboxamide, 2-butoxy-N-(2-(diethylamino)ethyl)-;2-butoxy-N-(alpha-diethylaminoethyl)cinchoninamide;CINCHOCAINE [MART.];CCG-220076;Cinchocaine [INN];SMR000058391;DTXCID1025271;NSC-159055;2-butoxy-N-(2-diethylaminoethyl)quinoline-4-carboxamide;CHEBI:247956;SCHEMBL23412539;Q-100863;BPBio1_000321;QUINOLINE,2-BUTOXY,4-CARBOXY,(N-TRIETHYLAMINO) AMIDE CINCHOCAIN;Spectrum4_000505;2-butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide;hydrochloride;NCGC00016338-01;PUFQVTATUTYEAL-UHFFFAOYSA-N;LS-53768;Cinchoninamide, 2-butoxy-N-[2-(diethylamino)ethyl]-;4-Quinolinecarboxamide, 2-butoxy-N-[2-(diethylamino)ethyl]-;NSC159055;HMS3886I10;Sovcaine (TN);AB00053453_25;KBio2_001408;NSC 159055;2-butoxy-N-[2-(diethylamino)et...
Cas No.	85-79-0
分子式	C₂₀H₂₉N₃O₂
分子量	343.46
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Dibucaine (Cinchocaine) 是一种钠通道抑制剂。 Dibucaine 是有效的 SChE 抑制剂。
生物活性	Dibucaine (Cinchocaine) is a sodium channel inhibitor. Dibucaine is a potent SChE inhibitor.
性状	Solid
体外研究(In Vitro)	Dibucaine (Cinchocaine) reduces the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain.Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch. has not independentl
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Souto-Padron, T., A.P. Lima, and O. Ribeiro Rde, Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi. Parasitol Res, 2006. 99(4): p. 317-20. [2]. Elamin, B., Dibucaine inhibition of serum cholinesterase. J Biochem Mol Biol, 2003. 36(2): p. 149-53.

溶解度数据	In Vitro: DMSO : 100 mg/mL (291.15 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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