Oxcarbazepine-d4|1020719-71-4|-陌孚医药/Medlife

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Oxcarbazepine-d4

目录号: PL11392

CAS No. :1020719-71-4

商品编号	规格	价格	会员价	是否有货	数量
PL11392-2.5mg	2.5mg	询价	询价
PL11392-25mg	25mg	询价	询价

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中文名称	Oxcarbazepine-d4
中文别名	10,11-二氢-10-氧代-5H-1,2,3,4-四氘代二苯并[B,F]氮杂卓-5-甲酰胺;奥卡西平 d4
英文名称	Oxcarbazepine-d4
英文别名	Oxcarbazepine-D4 (Major);1,2,3,4-tetradeuterio-6-oxo-5H-benzo[b][1]benzazepine-11-carboxamide;Oxcarbazepine-D4 (Major) ;[2H4]-Oxcarbazepine;Aurene-d4;Oxacarbazepine-d4;Oxecarb-d4;Oxetol-d4;Trileptal-d4;GP 47680-d4;10,11-Dihdyro-10-oxo-5H-dibenz[b,f]azepine-5-carboxaMide-d4;10,11-Dihdyro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide-D4, Trileptal-D4;10,11-Dihydro-10-oxo-5H-dibenz[b,f]azepine-1,2,3,4-d4-5-carboxamide;Oxcarbazepine-d4
Cas No.	1020719-71-4
分子式	C₁₅H₁₂N₂O₂
分子量	252.27
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Oxcarbazepine-d₄ 是 Oxcarbazepine 的氘代物。Oxcarbazepine 是一种钠通道 (sodium channel) 阻滞剂。Oxcarbazepine 有效抑制胶质母细胞瘤细胞生长并诱导胶质母细胞瘤细胞凋亡 (apoptosis) 或 G2/M 停滞。具有抗癌和抗惊厥作用。
生物活性	Oxcarbazepine-d 4 (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker[1]. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines[2]. Anti-cancer and anticonvulsant effects[2][3].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Ashley M Thomas, et al. Old Friends With New Faces: Are Sodium Channel Blockers the Future of Adjunct Pain Medication Management?J Pain. 2018 Jan;19(1):1-9. [3]. Ching-Yi Lee

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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