TPC2-A1-P 是一种强大的膜渗透性的双孔通道 2 (TPC2) 激动剂 (EC₅₀=10.5 μM)，它通过模仿 PI(3,5)P2 的生理作用发挥作用。与 TPC2-A1-N (HY-131614) 相比，TPC2-A1-P 具有更高的诱导 Na⁺ 活化的能力，可用于检测完整细胞中 TPC2 通道的不同功能。

TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC 50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na mobilisation from TPC2 than TPC-A1-N (HY-131614). TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells.

Solid

EC50: 10.5 μM (TPC2)

Two-pore channels (TPC1-3) are ancient members of the voltage-gated ion channel superfamily. TPCs are expressed throughout the endo-lysosomal system and regulates the trafficking of various cargoes.
TPC2 can mediate different physiological and possibly pathophysiological effects depending on how it is activated. The ion selectivity of TPC2 is not fixed but rather agonist-dependent. TPC2 is a unique example of an ion channel that conducts different ions in response to different activating ligands.
TPC2-A1-P (10 μM) reproducibly evokes Ca signals, and TPC2-A1-P response reachs its plateau slower than TPC2-A1-N (HY-131614). The EC50 in full concentration-effect relationships for the plateau response is 10.5 μM for TPC2-A1-P in a cell line stably expressing TPC2.
TPC2-A1-P (10-30 μM) induces Ca signals in Hela cells expressing TPC2 in t

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Powder -20°C 3 years；4°C 2 years

[1]. Susanne Gerndt, et al. Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. Elife. 2020 Mar 16;9:e54712.
[2]. Gerndt S, et al. Discovery of lipophilic two-pore channel agonists. FEBS J. 2020;287(24):5284-5293.
[3]. Xuhui Jin, et al. Targeting Two-Pore Channels: Curre

In Vitro: DMSO : 50 mg/mL (108.63 mM; Need ultrasonic)配制储备液