(+)-Norfenfluramine|19036-73-8|((S)-1-(3-(三氟甲基)苯基)丙-2-胺)-陌孚医药/Medlife

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(+)-Norfenfluramine (Synonyms: (S)-1-(3-(三氟甲基)苯基)丙-2-胺)

目录号: PL06557 纯度: ≥99%

CAS No. :19036-73-8

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中文名称	(+)-Norfenfluramine
中文别名	(S)-1-(3-三氟甲基苯基)-2-氨基丙烷
英文名称	(+)-Norfenfluramine
英文别名	Benzeneethanamine, a-methyl-3-(trifluoromethyl)-, (aS)-;(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-AMINOPROPANE;(+)-1-(3-aminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile;(+)-didesmethylcitalopram;(2S)-2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]propanoic acid;(S)-didesmethylcitalopram;(S)-N-didemethyl-citalopram;(S)-norfenfluramine;Dexibuprofen Lysine;d-norfenfluramine;nor-(+)-fenfluramine;S-(+)-didesmethyl citalopram;S(+)-ibuprofen lysinate monohydra;S-(+)-norfenfluramine;UNII-JM43W5556T;Einecs 242-769-7;S-Norfenfluramine;Nordexfenfluramine;Dexnorfenfluramine;(S)-1-(3-TRIFLUOROMETHYLPHENYL)-2-PROPANAMINE;(S)-1-(3-(trifluoromethyl)phenyl)propan-2-amine;(S)-α-Methyl-3-(trifluoromethyl)benzeneethanamine;(S)-alpha-methyl-m-(trifluoromethyl)phenethylamine;[S,(+)]-α-Methyl-m-(trifluoromethyl)phenethylamine;MFCD00671675;Norfenfluramine (-);(S)-1-(3-Trifluoromethyl-phenyl)-2-aminopropane;BENZENEETHANAMINE, .ALPHA.-METHYL-3-(TRIFLUOROMETHYL)-, (S)-;Norfenfluramine, (+)-;BENZENEETHANAMINE, .ALPHA.-METHYL-3-(TRIFLUOROMETHYL)-, (.ALPHA.S)-;CS-0197703;EINECS 242-769-7;LS-193348;PHENETHYLAMINE, .ALPHA.-METHYL-M-(TRIFLUOROMETHYL)-, (S)-;Norfenfluramine, (S)-;(+)-norfenfluramine;CHEBI:125533;AKOS027378233;(S)-Norfenfluramine;CHEMBL253811;BDBM85530;SCHEMBL4668266;(2S)-1-[3-(trifluoromethyl)phenyl]propan-2-amine;CLX07A6ZIY;PDSP1_001424;NCGC00186044-01;Nor-dexfenfluramine;PDSP1_000698;PDSP2_001406;Q27088005;PDSP2_001408;SDCCGSBI-0633814.P001;d-Norfenfluramine;EN300-1932182;UNII-CLX07A6ZIY;Norfenfluramine (+);D0U7BH;BRD-K31460632-001-01-8;GTPL216;MLBHFBKZUPLWBD-ZETCQYMHSA-N;Nor-d-fenfluramine;PDSP2_000688;AS-69910;(S)-alpha-Methyl-m-(trifluoromethyl)phenethylamine;19036-73-8;Benzeneethanamine, alpha-methyl-3-(trifluoromethyl)-, (alphaS)-
Cas No.	19036-73-8
分子式	C₁₀H₁₂F₃N
分子量	203.20
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	(+)-Norfenfluramine 是 (+)-fenfluramine 的主要肝脏代谢物，是一种选择性的 5-HT_2B 受体激动剂 (K_i: 11.2 nM)。(+)-Norfenfluramine 有效地刺激磷酸肌醇的水解并增加细胞内 Ca²⁺。(+)-Norfenfluramine 可用于原发性肺动脉高压和心脏瓣膜病的研究。
生物活性	(+)-Norfenfluramine a major hepatic metabolite of (+)-fenfluramine, is a selective 5-HT 2B receptor agonist (K i : 11.2 nM). (+)-Norfenfluramine potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca. (+)-Norfenfluramine can be used for the research of primary pulmonary hypertension and valvular heart disease.
性状	Liquid
IC50 & Target[1][2]	5-HT2B Receptor 11.2 nM (Ki) 5-HT2A Receptor
体外研究(In Vitro)	(+)-Norfenfluramine (1 nM to 100 μM) contracts arteries with a dramatic decrease in threshold (aorta and mesenteric resistance artery) in rats. (+)-Norfenfluramine (1 and 10 μM, 3 min) induces contraction in aorta from tissues of normotensive and hypertensive rats. (+)-Norfenfluramine (0-10 μM, 3 min) induces 5-HT release from rat hippocampal synaptosomes by Ca-dependent way . has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	(+)-Norfenfluramine (1-300 μg/kg, i.v.) induces pressor response in conscious SHAM and DOCA-salt rats. (+)-Norfenfluramine (2.5 and 5 mg/kg, i.p.) decreases of 5-HT and 5-HIAA levels in telencephalon and brainstem of rats. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Wei Ni, et al. The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. 2007 May;321(2):485-91. [2]. M Gobbi, et al. In vitro studies on the mechanism by which (+)-norfenfluramine induces serotonin and dopamine release from the vesicular storage pool. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):323-7.

溶解度数据	In Vitro: DMSO : 100 mg/mL (492.13 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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