Flibanserin|167933-07-5|(氟立班丝氨; BIMT-17; BIMT-17BS)-陌孚医药/Medlife

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Flibanserin (Synonyms: 氟立班丝氨; BIMT-17; BIMT-17BS)

目录号: PL05213 纯度: ≥99%

CAS No. :167933-07-5

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中文名称	Flibanserin
中文别名	氟立班丝氨;3-[2-[4-[4-(三氟甲基)苯基]哌嗪-1-基]乙基]-1H-苯并咪唑-2-酮;氟班色林;3-(3-异氰酸丙酯基)七甲基三硅氧烷;氟班色林标准品;氟立班丝氨(氟班色林);氟立班丝氨,氟班色林;氟立班丝氨：氟立班丝氨(碱性);氟立班丝氨(碱性);氟利班丝氨;热销氟立班丝氨;氟立班丝胺;尼蒙尔克素
英文名称	Flibanserin
英文别名	Flibanserin;3-[2-[4-[4-(Trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one;Filbanserin;Flibanserin,Bimt 17 Bimt-17-BS,Girosa;1-(2-(4-(3-Trifluoromethylphenyl)piperazin-1-yl)ethyl)benzimidazol(1H)-2-one;1,3-Dihydro-1-(2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl)-2H-benzimidazol-2-one;Bimt 17;BIMT-17;BIMT-17BS;1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one;BIMT 17BS;Flibanerins;Flibanserin(BIMT17);Flibanserin,Bimt 17, Bimt-17-BS,Girosa;Flibanserin ada@tuskwei.com sky;crystal paracetamol Flibanserin CAS NO.167933-07-5;Addyi;Girosa;37JK4STR6Z;BIMT 17 BS;Female Viagra [Street Name];1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one;3-[2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]-1H-benzimidazol-2-one;Female Viagra (Street Name);1,3-Dihy
Cas No.	167933-07-5
分子式	C₂₀H₂₁F₃N₄O
分子量	390.40
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Flibanserin (BIMT-17; BIMT-17BS) 是一种具有口服活性的 5- 羟色胺的 5-HT_1A 受体激动剂和 5-HT_2A 受体拮抗剂，结合亲和力 K_i 分别为 1 nM 和 49 nM。Flibanserin 也能够结合多巴胺 D4 受体，K_i 为 4-24 nM。Flibanserin 具有抗抑郁和抗焦虑作用，可用于性欲减退 (HSDD) 的研究。

生物活性

Flibanserin (BIMT-17; BIMT-17BS) is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with K i values of 1 nM and 49 nM, respectively. Flibanserin binds to dopamine D4 receptors with an K i value of 4-24 nM. Flibanserin shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research.

性状

Solid

IC50 & Target[1][2]

5-HT1A Receptor 1 nM (Ki) 5-HT2A Receptor

体外研究(In Vitro)

Flibanserin (0.01-100 μM; 72 h) can transform into two degradation products DP1 and DP2 with no toxicity potential after oxidative degradation.
has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay

体内研究(In Vivo)

Flibanserin (1, 10, 30 mg/kg; i.p.; single dose) shows different pharmacological properties in prefrontal cortex, hippocampus and midbrain. The 5-HT1A receptor occupancy in cortex indicates it’s the more sensitive than other brain region.
Flibanserin (15, 45 mg/kg; p.o.; twice a day; 22 d) preferentially activates the brain regions belonging to the mesolimbic dopaminergic pathway and hypothalamic structures involved in the integration of sexual cues related to sexual motivation.
Flibanserin (5, 10, 25, and 50 mg/kg; s.c.; single dose) has anxiolytic effects without locomotor side effects in rat ultrasonic vocalization model.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Fayed M, et al. Insights into Flibanserin Oxidative Stress Degradation Pathway: In Silico – In Vitro Toxicity Assessment of Its Degradates[J]. New Journal of Chemistry, 2021.
[2]. Invernizzi RW, et al. A potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors. Br J Pharmacol. 2003 Aug;139(7):1281-8.

溶解度数据	In Vitro: DMSO : 50 mg/mL (128.07 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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