Naftidrofuryl oxalate (Synonyms: 草酸萘呋胺; Nafronyl oxalate salt)
目录号: PL05461 纯度: ≥98%
CAS No. :3200-06-4
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中文名称
Naftidrofuryl oxalate
中文别名
草酸萘呋胺;萘呋胺酯草酸盐;alpha-(1-萘甲基)-2-四氢呋喃丙酸二乙胺基乙基酯草酸盐;唑拉西泮草酸盐标准品;α-(1-萘基甲基)-2-四氢呋喃丙酸二乙氨基乙酯
英文名称
Naftidrofuryl oxalate
英文别名
2-(Diethylamino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate oxalate;Naftidrofuryl oxalate;alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate;Nafronyl oxalate salt;diethyl{2-[2-(1-naphthylmethyl)-3-(tetrahydro-2-furyl)propionyloxy]ethyl}ammonium hydrogen oxalate;Dubimax;Dusodril;Iridus;LS-121;nafronyl acid oxalate;nafronyl oxalate;Praxilene
Cas No.
3200-06-4
分子式
C24H33NO3.C2H2O4
分子量
473.56
包装储存
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
产品详情
Naftidrofuryl oxalate (Nafronyl oxalate salt) 是在外周血和脑血管病症如血管扩张药的管理中使用的药物, 增加细胞氧化能力, 且是一种 5-HT2 受体拮抗剂。
生物活性
Naftidrofuryl oxalate (Nafronyl oxalate salt) is a drug used in the management of peripheral and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.
性状
Solid
IC50 & Target[1][2]
5-HT2 Receptor
体外研究(In Vitro)
Naftidrofuryl oxalate (Nafronyl oxalate salt) may be effective for relieving the pain of muscle cramps.
Naftidrofuryl oxalate (Nafronyl oxalate salt) is the only vasoactive drug for peripheral arterial disease (PAD) which is likely to be cost-effective.
Naftidrofuryl oxalate (Nafronyl oxalate salt) is ranked first for both maximum walking distance (MWD) and pain-free walking distance (PFWD) (probability of 0·947 and 0·987, respectively, of being the best treatment) followed by cilostazol and pentoxifylline. Naftidrofuryl oxalate (Nafronyl oxalate salt) is effective treatments for claudication, Naftidrofuryl oxalate is likely to be the most effective, with minimal serious adverse events. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献
[1]. Naftidrofuryl
[2]. Meng Y, et al. Cost-effectiveness of cilostazol, naftidrofuryl oxalate, and pentoxifylline for the treatment of intermittent claudication in people with peripheral arterial disease. Angiology. 2014 Mar;65(3):190-197.
[3]. Stevens JW, et al. Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for t
溶解度数据
In Vitro: DMSO : ≥ 100 mg/mL (211.17 mM)H2O : 100 mg/mL (211.17 mM; Need ultrasonic)
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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