Spadin TFA||-陌孚医药/Medlife

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Spadin TFA

目录号: PL05848 纯度: ≥99%

商品编号	规格	价格	会员价
PL05848-1mg	1mg	¥2893.00	请登录
PL05848-5mg	5mg	¥8679.00	请登录
PL05848-10mg	10mg	询价	询价
PL05848-50mg	50mg	询价	询价

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中文名称	Spadin TFA
英文名称	Spadin TFA
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情	Spadin TFA 是一种从血液中释放的前肽衍生的天然肽，是一种有效的 TREK-1 通道阻滞剂，其 IC₅₀ 值为 10 nM。Spadin TFA 增强小鼠中缝背核 5-HT 神经传递，诱导海马 CREB 激活和神经发生。Spadin TFA 可用于抗抑郁研究。
生物活性	Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC 50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin TFA can be used for antidepressant research.
性状	Solid
体外研究(In Vitro)	Spadin TFA (100 nM; COS-7 cells) has inhibitory effect of spadin on the TREK-1 channel and blocks 63% of the TREK-1 current stimulated by arachidonic acid. Spadin TFA (100 nM) blocks the TREK-1 channels activity in CA3 hippocampal neurons on brain slices of wild-type mice. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Spadin TFA (10 μM, 100 μL; i.p.; for 30 min; male C57Bl/6J and TREK-1 deficient mice) increases of the 5-HT neuron firing rate in the dorsal raphe nucleus (DRN). Spadin TFA (0.01-100 μM, 100 μL; ICV, i.p. and i.v.; daily, for 7 days; male C57Bl/6J and TREK-1 deficient mice) has anti-depressant behavior in mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
SequenceShortening	YAPLPRWSGPIGVSWGLR
参考文献	[1]. Borsotto M, et, al. Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. Br J Pharmacol. 2015 Feb;172(3):771-84. [2]. Mazella J, et, al. Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 2010 Apr 13;8(4):e1000355.

溶解度数据	In Vitro: H₂O : 25 mg/mL (11.76 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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