Paliperidone-d4|1020719-55-4|-陌孚医药/Medlife

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Paliperidone-d4

目录号: PL05199

CAS No. :1020719-55-4

商品编号	规格	价格	会员价	是否有货	数量
PL05199-1mg	1mg	询价	询价
PL05199-5mg	5mg	询价	询价

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中文名称	Paliperidone-d4
中文别名	[ 2H4 ] -帕潘立酮标准品;C-(1-环戊基-哌啶-4-基)-甲胺;RAC-9羟利培酮D4;3-[2-[4-(6-氟-1,2-苯并异恶唑-3-基)-1-哌啶基]乙基-1,1,2,2-d4]-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮;3-[2-[4-(6-氟-1,2-苯并异恶唑-3-基)-1-哌啶基]乙基-1,1,2,2-D4]-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-A]嘧啶-4-酮
英文名称	Paliperidone-d4
英文别名	rac 9-Hydroxy Risperidone-d4;9-Hydroxyrisperidone-D4 solution;Paliperidone-d4;[2H4]-Paliperidone;9-Hydroxyrisperidone-d4;Invega-d4;n-4-one deriv.;Paliperidone-d4 (Major);Risperidone Imp. C (EP)-d4;R 76477-d4;RO 76477-d4;rac 9-Hydroxy Risperidone-d4See P141002;9-Hydroxy Risperidone-d4 (Paliperidone-d4);3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl-d4]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one;3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl- 4H-pyrido[1,2-α]pyrimidin-4-one-d4;9-hydroxy-2-methyl-3-[1,1,2,2-tetradeuterio-2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one;4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl-1,1,2,2-d4]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-;3-{2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl](~2~H_4_;RAC 9-HYDROXYRISPERIDONE-D4
Cas No.	1020719-55-4
分子式	C₂₃H₂₇FN₄O₃
分子量	430.51
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Paliperidone-d₄ 是 Paliperidone 的氘代物。Paliperidone (9-Hydroxyrisperidone) 是 Risperidone 的主要活性代谢产物，是多巴胺 D2 (dopamine D2) 拮抗剂和 5-HT2A 拮抗剂。Paliperidone 对 α1 和 α2 肾上腺素能受体和 H1 组胺能受体也有拮抗作用。Paliperidone 是一种抗精神病药物，对精神分裂症有效。
生物活性	Paliperidone-d 4 is the deuterium labeled Paliperidone. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia[1].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Mauri MC, Paletta S, Maffini M, et al. Clinical pharmacology of atypical antipsychotics: an update. EXCLI J. 2014;13:1163-1191. Published 2014 Oct 13. [3]. Peng L, et al. Pa

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