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| 商品编号 | 规格 | 价格 | 会员价 | 是否有货 | 数量 |
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| PL04228-5mg | 5mg | ¥2989.00 | 请登录 |
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| PL04228-10mg | 10mg | ¥5082.00 | 请登录 |
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| PL04228-50mg | 50mg | ¥13452.00 | 请登录 |
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| PL04228-100mg | 100mg | 询价 | 询价 |
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| PL04228-200mg | 200mg | 询价 | 询价 |
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| PL04228-10mM*1mLinDMSO | 10mM*1mLinDMSO | ¥3288.00 | 请登录 |
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| 中文名称 |
Adoprazine
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|---|---|
| 中文别名 |
阿哆嗪;1-(2,3-二氢-1,4-苯并二恶烷-5-基)-4-[[5-(4-氟苯基)-3-吡啶基]甲基]哌嗪
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| 英文名称 |
Adoprazine
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| 英文别名 |
Adoprazine;1-(2,3-Dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)-3-pyridinyl]methyl]piperazine;1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluorophenyl)pyridin-3-yl]methyl]piperazine;SLV 313;SLV-313
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| Cas No. |
222551-17-9
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| 分子式 |
C24H24N3O2F
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| 分子量 |
405.46
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| 包装储存 |
Powder -20°C 3 years；4°C 2 years
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| 产品详情 |
Adoprazine (SLV313) 是 5-HT 1A 受体的完全激动剂，其在 h5-HT1A 受体的 pEC50 为 9。Adoprazine (SLV313) 是 D2 和 D3 受体的完全拮抗剂，在 hD2 受体中的 pA2 值是 9.3，在 hD3 受体中的 pA2 值是 8.9。Adoprazine (SLV313) 具有非典型抗精神病的特征。
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| 生物活性 |
Adoprazine (SLV313) is a full 5-HT 1A receptor agonist with a pEC 50 of 9 at cloned h5-HT 1A receptors. Adoprazine (SLV313) is a full D 2 and D 3 receptor antagonist with pA 2 s of 9.3 and 8.9 at hD 2 and hD 3 receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
5-HT1A Receptor 9 (pEC50) D2 Receptor
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| 体外研究(In Vitro) |
Adoprazine (SLV313) has high affinity at human recombinant D2, D3, D4, 5-HT2B, and 5-HT1A receptors, with pKis of 8.4, 8.4, 8.0, 7.9 and 9.1, respectively. Adoprazine (SLV313) acts as a high potency dopamine D2 receptor antagonist and an efficacious serotonin 5-HT1A receptor agonist, with Emax value (% effect of 10 μM 5-HT) of 73 and pKB value of 8.5 . has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
Adoprazine (SLV313) (0.1-10 mg/kg; p.o.; single) is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner. has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Powder -20°C 3 years；4°C 2 years
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| ClinicalTrial |
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| 参考文献 |
[1]. Andrew C McCreary, et al. SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsych[2]. Liesbeth A Bruins Slot, et al. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. Eur J Pharmacol. 2006 Mar 18;534(1-3):63-70.
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| 溶解度数据 |
In Vitro: DMSO : 50 mg/mL (123.32 mM; Need ultrasonic)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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