PRX-07034 hydrochloride 是一种有效的高度选择性 5-HT6 受体拮抗剂，K_i 为 4-8 nM，IC₅₀ 为 19 nM。PRX-07034 可用于增强工作记忆和认知灵活性的研究。

PRX-07034 hydrochloride is a highly selective and potent 5-HT6 receptor antagonist with a K i = 4-8 nM and an IC 50 of 19 nM. PRX-07034 can be used for the research of enhancing working memory and cognitive flexibility.

Solid

5-HT6 Receptor 4-8 nM (Ki) 5-HT6 Receptor

PRX-07034 is both a potent and highly selective 5-HT6 receptor antagonist (≥100-fold selectivity for the 5-HT6 receptor compared to 68 other GPCRs, ion channels, and transporters. PRX-07034 inhibits 5-HT1A, 5-HT1B, 5-HT1D, Dopamine D3, Histamine H2, and Opioid μ receptor with Kis of 420 nM, 260 nM, 2.8 μM, 71 nM, 0.64 μM, and 0.45 μM, respectively. PRX-07034 inhibits 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50s of 2.5 μM, 2.5 μM, and 3.7 μM, respectively.
In functional assays, PRX-07034 demonstrates low antagonist activity for the dopamine D3 receptor (IC50=4.8 μM) and very low agonistic activity for the opioid μ-receptor (EC50=19 μM) . has not independently confirmed the accuracy of these methods. They are for reference only.

PRX-07034 (0.1, 1, or 3 mg/kg; i.p.; 30 min prior to delayed spontaneous alternation testing) selectively enhances a switch to a place discrimination. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

[1]. Eric G Mohler, et al. The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology (Berl). 2012 Apr;220(4):687-96.

In Vitro: DMSO : 31.25 mg/mL (63.72 mM; ultrasonic and warming and heat to 60°C)H₂O : 4.76 mg/mL (9.71 mM; Need ultrasonic)配制储备液