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DOI hydrochloride

目录号: PL01389 纯度: ≥99%

DOI hydrochloride 是一种血清素 5-HT2A/2C 受体激动剂，对 h5-HT2A、h5-HT2C 和 h5-HT2B 受体的 Ki 值分别为 0.7 nM、2.4 nM 和 20 nM。DOI hydrochloride 可以透过血脑屏障。DOI hydrochloride 会增加小鼠的头部抽搐。

CAS No. :42203-78-1

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PL01389-200mg	200mg	询价	询价
PL01389-500mg	500mg	询价	询价

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中文名称	DOI hydrochloride
中文别名	(±)-2,5-二甲氧基-4-碘苯丙胺盐酸盐(DOI盐酸盐标准品;4-碘-2,5-二甲氧基-α-甲基-苯乙胺盐酸;苯丙胺类,建议不做
英文名称	DOI hydrochloride
英文别名	Benzeneethanamine,4-iodo-2,5-dimethoxy-a-methyl-, hydrochloride (1:1);(±)-2,5-Dimethoxy-4-Iodoamphetamine hydrochloride solution;(±)-DOI hydrochloride;Benzeneethanamine, 4-iodo-2,5-dimethoxy-α-methyl-, hydrochloride;DOI (hydrochloride);DOI HYDROCHLORIDE;DOI hydrochloride,4-Iodo-2,5-dimethoxy-α-methylbenzeneethanaminehydrochloride;(±)-DOI;(±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride;(±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride
Cas No.	42203-78-1
分子式	C₁₁H₁₆NO₂I^.HCl
分子量	357.62
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	DOI hydrochloride 是一种血清素 5-HT2A/2C 受体激动剂，对 h5-HT2A、h5-HT2C 和 h5-HT2B 受体的 Ki 值分别为 0.7 nM、2.4 nM 和 20 nM。DOI hydrochloride 可以透过血脑屏障。DOI hydrochloride 会增加小鼠的头部抽搐。

产品详情	DOI hydrochloride 是一种血清素 5-HT_2A/_2C 受体激动剂，对 h5-HT_2A、h5-HT_2C 和 h5-HT_2B 受体的 K_i 值分别为 0.7 nM、2.4 nM 和 20 nM。DOI hydrochloride 可以透过血脑屏障。DOI hydrochloride 会增加小鼠的头部抽搐。
生物活性	DOI hydrochloride is a serotonin 5-HT 2A / 2C receptor agonist with K i values of 0.7 nM, 2.4 nM and 20 nM for h5-HT 2A , h5-HT 2C and h5-HT 2B receptors, respectively. DOI hydrochloride can across the blood-brain barrier. DOI hydrochloride increases head twitches in mice.
性状	Solid
IC50 & Target[1][2]	Human 5-HT2A Receptor 0.7 nM (Ki) Human 5-HT2C Receptor
体外研究(In Vitro)	DOI hydrochloride (10 μM; for 45 min) causes a massive increase in adhesion with 99% of the cells staying adherent compared to only 42% of untreated Hu2AAB1 cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	DOI hydrochloride (0.3-10 mg/kg; i.p.; single dose) produces an increase in mean head twitches at 3 mg/kg in Wild type (WT) ICR (CD-1) KO mice. Lower doses produces non-significant increases in head twitches, while a higher dose of 10 mg/kg produces increased variability yet a significant increase in mean head twitches. DOI (0.35-0.7 mmol/kg; sc) significantly increases waking and light sleep and reduces slow wave sleep, rapid-eye-movement (REM) sleep, and the number of REM periods in Male Wistar rats weighing 350-400 g. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. D L Nelson, et al. Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jan;359(1):1-6. [2]. S L Shepheard, et al. Investigation of the effects of IVth ventricular administration of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), on autonomic outflow in the anaesthetized cat. Br J Pharmacol. 1991 Oct;104(2):367-72.

溶解度数据	In Vitro: H₂O : 25 mg/mL (69.91 mM; Need ultrasonic)配制储备液

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[1]. D L Nelson, et al. Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jan;359(1):1-6.
[2]. S L Shepheard, et al. Investigation of the effects of IVth ventricular administration of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), on autonomic outflow in the anaesthetized cat. Br J Pharmacol. 1991 Oct;104(2):367-72.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

DOI hydrochloride

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