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LY334370

目录号: PL01387 纯度: ≥99%

LY334370 是一个选择性的 5-HT1F 受体激动剂，其 Ki 值为 1.6 nM。

CAS No. :182563-08-2

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中文名称	LY334370
中文别名	4-氟-N-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯甲酰胺盐酸盐;4-氟-n-(3-(1-甲基哌啶-4-基)-1H-吲哚-5-基)苯脒盐酸盐
英文名称	LY334370
英文别名	4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]-Benzamide;4-fluoro-N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]benzamide;LY 334370 HYDROCHLORIDE;LY 334370;LY-334370 hydrochloride hydrate;4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide;4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-indol-5-yl]-benzamide;BenzaMide, 4-fluoro-N-[3-(1-Methyl-4-piperidinyl)-1H-indol-5-yl]-;4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamidehydrochloride;4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benazmide hydrochloride;4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benzamide hydrochloride;4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate;LY334370
Cas No.	182563-08-2
分子式	C₂₁H₂₂N₃OF
分子量	351.42
包装储存	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
详情描述	LY334370 是一个选择性的 5-HT1F 受体激动剂，其 Ki 值为 1.6 nM。

产品详情	LY334370 是一个选择性的 5-HT_1F 受体激动剂，其 K_i 值为 1.6 nM。
生物活性	LY334370 is a selective 5-HT 1F receptor agonist with a K i of 1.6 nM.
性状	Solid
IC50 & Target[1][2]	5-HT1F Receptor 1.6 nM (Ki)
体外研究(In Vitro)	LY334370 has no vasoconstrictor effects on human cerebral arteries in vitro until a dose of 10 M, at which it produces a contraction of 8.5±5.7%; however, this is not significant. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Following intravenous administration of LY334370 at 3 mg/kg (n=3) or 10 mg/kg (n=6) electrical stimulation evokes an increase in dural blood vessel diameter of 135±6% and 106±11%, respectively, which is not significantly different from the respective control values. LY334370 has no effect on dural blood vessel diameter per se, since the actual dural blood vessel diameter is 43±4 arbitrary units before drug and 43±4 arbitrary units 15 min after injection of LY334370 (10 mg/kg). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Shepheard S, et al. Possible antimigraine mechanisms of action of the 5HT1F receptor agonist LY334370. Cephalalgia. 1999 Dec;19(10):851-8.

溶解度数据	In Vitro: DMSO : ≥ 55.5 mg/mL (157.93 mM)配制储备液

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[1]. Shepheard S, et al. Possible antimigraine mechanisms of action of the 5HT1F receptor agonist LY334370. Cephalalgia. 1999 Dec;19(10):851-8.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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