Alniditan dihydrochloride|155428-00-5|-陌孚医药/Medlife

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Alniditan dihydrochloride

目录号: PL01270

Alniditan (Alnitidan) dihydrochloride 是一种有效的 5-HT1B 和 5-HT1D 受体激动剂，在 HEK 293 细胞中，对人 5-HT1B 和人 5-HT1D 受体的 IC50 分别为 1.7 nM 和 1.3 nM。Alniditan dihydrochloride 具有预防偏头痛的作用。

CAS No. :155428-00-5

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中文名称	Alniditan dihydrochloride
中文别名	阿尼地坦
英文名称	Alniditan dihydrochloride
英文别名	1,3-Propanediamine,N1-[[(2R)-3,4-dihydro-2H-1-benzopyran-2-yl]methyl]-N3-(1,4,5,6-tetrahydro-2-pyrimidinyl)-,hydrochloride (1:2);1,3-Propanediamine,N1-[[(2R)-3,4-dihydro-2H-1-benzopyran-2-yl]methyl]-N3-(1,4,5,6-tetrahydro-2...;1,3-Propanediamine,N1-[[(2R)-3,4-dihydro-2H-1-benzopyran-2-yl]methyl]-N3-(1,4,5,6-tetrahydro-2-pyrimidinyl)-,hydrochloride (1;alniditan
Cas No.	155428-00-5
分子式	C₁₇H₂₆N₄O^.₂[HCl]
分子量	375.34
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Alniditan (Alnitidan) dihydrochloride 是一种有效的 5-HT_1B 和 5-HT_1D 受体激动剂，在 HEK 293 细胞中，对人 5-HT_1B 和人 5-HT_1D 受体的 IC₅₀ 分别为 1.7 nM 和 1.3 nM。Alniditan dihydrochloride 具有预防偏头痛的作用。
生物活性	Alniditan (Alnitidan) dihydrochloride is a potent 5-HT 1B and 5-HT 1D receptors agonist, with IC 50 s of 1.7 nM and 1.3 nM for h5-HT 1B and h5-HT 1D receptors in HEK?293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects.
性状	Solid
IC50 & Target[1][2]	human 5-HT1B Receptor 1.7 nM (IC50) human 5-HT1D Receptor
体外研究(In Vitro)	In vitro, Alniditan exhibits little vasoconstrictive effects on the rat basilar artery, although at a very high concentration 1 mM, Alniditan causes intensive constriction, most likely through a mechanism independent from 5-HT receptor activation. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The intraperitoneal administration of Alniditan ED 50 =9 μg/kg dose dependly reduces [I]-BSA extravasation in the rat meninges when done 30 min before stimulation. Alniditan dose dependently attenuateds the neurogenic inflammation in vivo model of neurogenic inflammation. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Limmroth V, et al. Effects of alniditan on neurogenic oedema in the rat dura mater and on contraction of rat basilar artery. Eur J Pharmacol. 1999 Oct 8;382(2):103-9. [2]. Lesage AS, et al. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol. 1998 Apr;123(8):1655-65.

溶解度数据	In Vitro: DMSO : 62.5 mg/mL (166.52 mM; Need ultrasonic)配制储备液

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