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Phenylbiguanide

(Synonyms: N-Phenylbiguanide; PBG; 1-Phenylbiguanide)

目录号: PL01215 纯度: ≥98%

Phenylbiguanide 是一种选择性的 5-HT3 受体激动剂，EC50 为 3.0±0.1 μM。

CAS No. :102-02-3

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中文名称	Phenylbiguanide
中文别名	苯基双胍;1-苯基双胍;Phenylbiguanide 苯基双胍;N-苯基亚氨基二碳亚氨酸二酰胺
英文名称	Phenylbiguanide
英文别名	Imidodicarbonimidicdiamide, N-phenyl-;Phenylbiguanide;1-(diaminomethylidene)-2-phenylguanidine;N-Phenyliminodicarbonimidic Diamide;p1426;phenyl-biguanid;phenyldiguanide;1-PHENYLBIGUANIDE;1-phenyl-biguanid;n-phenyl-n’-guanylguanidine;2-(N2-Phenylamidino)guanidine;N-PHENYLIMINODICARBONIMIDIC-DIAMIDE;Phenyl biguanide;Phenylguanide;phenyl diguanide;N-Phenyl-N'-guanylguanidine;N-phenylimidodicarbonimidic diamide;Imidodicarbonimidic diamide, N-phenyl-;Biguanide, phenyl-;BIGUANIDE, 1-PHENYL-;C8H11N5;N-Phenyl-imidocarbonimidic diamide;W8PKA3T2I3;P 1426;N-phenylbiguanide;N'-phen;N-Phenylbiguanide;PBG;1-Phenylbiguanide;PHENYLBIGUANIDE
Cas No.	102-02-3
分子式	C₈H₁₁N₅
分子量	177.21
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Phenylbiguanide 是一种选择性的 5-HT3 受体激动剂，EC50 为 3.0±0.1 μM。

产品详情	Phenylbiguanide 是一种选择性的 5-HT₃ 受体激动剂，EC₅₀ 为 3.0±0.1 μM。
生物活性	Phenylbiguanide is a 5-HT 3 receptor selective agonist with an EC 50 of 3.0±0.1 μM.
性状	Solid
IC50 & Target[1][2]	5-HT3 Receptor 3 μM (EC50)
体外研究(In Vitro)	Phenylbiguanide (1-Phenylbiguanide) is a 5-HT3 receptor selective agonist with pEC50s of 5.57, 4.07, and 4.47 for r5-HT3A(b), h5-HT3A, m5-HT3A(b) , respectively. The effect of Phenylbiguanide (1-Phenylbiguanide hydrochloride) in promoting the growth of the HT29 cell line is investigated. Phenylbiguanide causes a dose dependent proliferation of HT29 cells after 48 hours incubation. The maximum proliferation is at a 5HT concentration of 12.5 μM (P≤0.01). Phenylbiguanide significantly stimulates the growth of cells at concentrations of 3.125 μM (P≤0.05) and 6.25 μM (P≤0.01). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Mair ID, et al. Pharmacological characterization of a rat 5-hydroxytryptamine type3 receptor subunit (r5-HT_3A(b)) expressed in Xenopus laevis oocytes. Br J Pharmacol. 1998 Aug;124(8):1667-74. [2]. Ataee R, et al. Study of 5HT3 and HT4 receptor expression in HT29 cell line and human colon adenocarcinoma tissues. Arch Iran Med. 2010 Mar;13(2):120-5.

溶解度数据	In Vitro: DMSO : 150 mg/mL (846.45 mM; Need ultrasonic)H₂O : ≥ 25 mg/mL (141.08 mM)

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[1]. Mair ID, et al. Pharmacological characterization of a rat 5-hydroxytryptamine type3 receptor subunit (r5-HT_3A(b)) expressed in Xenopus laevis oocytes. Br J Pharmacol. 1998 Aug;124(8):1667-74.
[2]. Ataee R, et al. Study of 5HT3 and HT4 receptor expression in HT29 cell line and human colon adenocarcinoma tissues. Arch Iran Med. 2010 Mar;13(2):120-5.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Phenylbiguanide

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