S 38093 是一种可透过大脑的，具有口服活性的 H3 receptor 拮抗剂，对大鼠，小鼠和人的 H3 受体具有不同的亲和力，K_i 值分别为 8.8，1.44 和 1.2 µM。

S 38093 is a brain-penetrant, orally active antagonist of H3 receptor, with K i s of 8.8, 1.44 and 1.2 μM for rat, mouse and human H3 receptors, respectively.

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Ki: 8.8 μM (Rat H3 receptor), 1.44 μM (Mouse H3 receptor), 1.2 μM (Human H3 receptor)

In cellular models, S 38093 is able to antagonize mice H3 receptors (KB=0.65 μM) and to suppress cAMP decrease induced by an H3 agonist via human H3 receptors (KB=0.11 μM). In cells expressing a high H3 density, S 38093 behaves as a moderate inverse agonist at rat and human H3 receptors (EC50=9 and 1.7 μM, respectively). has not independently confirmed the accuracy of these methods. They are for reference only.

S 38093 (0.3 and 3?mg/kg/d p.o., 28 days) significantly increases proliferation of progenitors in the DG of hippocampus in young adult mice. S 38093 (0.3?mg/kg/d) treatment significantly increases the number of DCX cells with tertiary dendrites. S 38093 (0.3, 1 and/or 3?mg/kg) significantly increases cell proliferation, survival, and maturation in the DG of hippocampus in aged mice relative to vehicle. S 38093 (3?mg/kg/d p.o., 28 days) increases cell proliferation and has a strong effect on cell survival, also increases the dendritic intersections in both genotypes (one-way ANOVA with repeated measure, p?<?0.01), with a significant effect from 50 to 80 in APPSWE mice only. In aged mice, chronic administration of S 38093 (1 and/or 3?mg/kg/day p.o., 28 days) reverses this age-dependent decrease in BDNF-IX, BDNF-IV and BDNF-I transcripts. In addition, S 38093 at three tested d

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Powder -20°C 3 years；4°C 2 years

[1]. Guilloux JP, et al. S 38093, a histamine H3 antagonist/inverse agonist, promotes hippocampal neurogenesis and improves context discrimination task in aged mice. Sci Rep. 2017 Feb 20;7:42946.
[2]. Sors A, et al. Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors. Eur J Pharmacol. 2017 May 15;803:11-23

In Vitro: DMSO : 2 mg/mL (6.94 mM; Need ultrasonic)配制储备液