您当前的位置：

INCB38579

目录号: PL14944 纯度: ≥99%

INCB38579 是一种具有口服活性、高度脑穿透和选择性的组胺 H4 受体 (HH4R) 拮抗剂 (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM)。INCB38579 具有抗炎和抗瘙痒的活性。

CAS No. :1246207-65-7

商品编号	规格	价格	会员价
PL14944-5mg	5mg	¥5625.00	请登录
PL14944-10mg	10mg	¥9643.00	请登录
PL14944-25mg	25mg	¥20090.00	请登录
PL14944-50mg	50mg	询价	询价
PL14944-100mg	100mg	询价	询价
PL14944-10mM*1mLinDMSO	10mM*1mLinDMSO	¥6188.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

*注意事项:下单时请联系销售核实产品价格及货期，避免后续产生不便，感谢支持!

加入购物车在线咨询收藏产品大包装询价

中文名称	INCB38579
英文名称	INCB38579
英文别名	Ethanone, 1-[7-[2-amino-6-(4-methyl-1-piperazinyl)-4-pyrimidinyl]-3,4-dihydro-2(1H)-isoquinolinyl]-2-cyclopentyl-;INCB38579
Cas No.	1246207-65-7
分子式	C₂₅H₃₄N₆O
分子量	434.58
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	INCB38579 是一种具有口服活性、高度脑穿透和选择性的组胺 H4 受体 (HH4R) 拮抗剂 (hH4R IC50=4.8 nM, mH4R IC50=42 nM, rH4R IC50=32 nM)。INCB38579 具有抗炎和抗瘙痒的活性。

产品详情	INCB38579 是一种具有口服活性、高度脑穿透和选择性的组胺 H₄ 受体 (HH₄R) 拮抗剂 (hH₄R IC₅₀=4.8 nM, mH₄R IC₅₀=42 nM, rH₄R IC₅₀=32 nM)。INCB38579 具有抗炎和抗瘙痒的活性。
生物活性	INCB38579 is an orally active, highly brain penetrable, and selective histamine H 4 receptor (HH 4 R) antagonist (hH 4 R IC 50 =4.8 nM, mH 4 R IC 50 =42 nM, rH 4 R IC 50 =32 nM). INCB38579 shows anti-inflammatory pain and anti-pruritic activities.
性状	Solid
IC50 & Target[1][2]	Human H4 Receptor 4.8 nM (IC50) Mouse H4 Receptor
体外研究(In Vitro)	INCB38579 (0.1 nM-10 μM; 1.5 h) inhibits histamine binding to the recombinant human and rodent histamine H4 receptors. INCB38579 (0.1 nM-10 μM; 20 min) blocks histamine-induced migration of dendritic cells differentiated from human monocytes and mouse bone marrow cells. NCB38579 (0-30 nM; 1.5 h) inhibits histamine-induced cell shape change and migration of purified human eosinophils dose-dependently. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	INCB38579 (oral gavage; 100 mg/kg; once) inhibits histamine-mediated pruritus in mice. INCB38579 (oral gavage; 100 mg/kg; once) shows antinociceptive functions in this acute model of inflammatory pain. INCB38579 (oral gavage; 3, 10, 30, and 100 mg/kg; once) inhibits formalin-induced pain in rats and mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Niu Shin, et al. INCB38579, a novel and potent histamine H? receptor small molecule antagonist with anti-inflammatory pain and anti-pruritic functions. Eur J Pharmacol. 2012 Jan 30;675(1-3):47-56.

溶解度数据	In Vitro: DMSO : 230 mg/mL (529.25 mM; ultrasonic and warming and heat to 60°C)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

[1]. Niu Shin, et al. INCB38579, a novel and potent histamine H? receptor small molecule antagonist with anti-inflammatory pain and anti-pruritic functions. Eur J Pharmacol. 2012 Jan 30;675(1-3):47-56.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

INCB38579

相关产品

The molarity calculator equation

The dilution calculator equation