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Cimetidine sulfoxide

(Synonyms: 西咪替丁亚砜; Cimetidine sulphoxide)

目录号: PL14948 纯度: ≥97.0%

Cimetidine sulfoxide (Cimetidine sulphoxide) 是一种 Cimetidine 的亚砜代谢产物。Cimetidine 是一种组胺 H2 受体 (H2-receptor) 拮抗剂，可用于消化性溃疡和上消化道出血的研究。

CAS No. :54237-72-8

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中文名称	Cimetidine sulfoxide
中文别名	双氰胺;西咪替丁亚砜盐酸盐;西咪替丁杂质E(EP) 标准品;西米替丁砜(EP杂质E);西米替丁砜盐酸盐;(±)-西咪替丁 S-氧化物
英文名称	Cimetidine sulfoxide
英文别名	Guanidine,N-cyano-N'-methyl-N''-[2-[[(4-methyl-1H-imidazol-5-yl)methyl]sulfinyl]ethyl]-;1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfinyl]ethyl]guanidine;Cimetidine Sulfoxide;Cimetidine sulphoxide dihydrochloride;SKF 92452;Cimetidine sulfoxide
Cas No.	54237-72-8
分子式	C₁₀H₁₆N₆Os
分子量	341.26
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months
详情描述	Cimetidine sulfoxide (Cimetidine sulphoxide) 是一种 Cimetidine 的亚砜代谢产物。Cimetidine 是一种组胺 H2 受体 (H2-receptor) 拮抗剂，可用于消化性溃疡和上消化道出血的研究。

产品详情	Cimetidine sulfoxide (Cimetidine sulphoxide) 是一种 Cimetidine 的亚砜代谢产物。Cimetidine 是一种组胺 H₂ 受体 (H₂-receptor) 拮抗剂，可用于消化性溃疡和上消化道出血的研究。
生物活性	Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H 2 -receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment.
性状	Solid
IC50 & Target[1][2]	Histamine H2-receptor
体外研究(In Vitro)	Active transport of Cimetidine across the rat small intestine is observable at lower substrate concentrations (40 and 200 μM), but is masked by passive transfer at higher concentrations (400 μM). Cimetidine sulfoxide is detected after some incubations. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The enantiomeric composition of Cimetidine sulfoxide is also determined in rat urine (24 h) following the administration of Cimetidine (30 mg/kg; po) to male Wistar rats. The enantiomeric ratio in this case is found to be (+/?) 57:43. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Larsson R, et al. The pharmacokinetics of cimetidine and its sulphoxide metabolite in patients with normal and impaired renal function. Br J Clin Pharmacol. 1982;13(2):163-170. [2]. HE Barber, et al. The Transport of Cimetidine Across the Rat Small Intestine in Vitro. B r J Pharmacol. 1979 Jul;66(3):496P-497P.

溶解度数据	In Vitro: DMSO : 83.33 mg/mL (310.54 mM; ultrasonic and warming and heat to 60°C)配制储备液

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[1]. Larsson R, et al. The pharmacokinetics of cimetidine and its sulphoxide metabolite in patients with normal and impaired renal function. Br J Clin Pharmacol. 1982;13(2):163-170.
[2]. HE Barber, et al. The Transport of Cimetidine Across the Rat Small Intestine in Vitro. B r J Pharmacol. 1979 Jul;66(3):496P-497P.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Cimetidine sulfoxide

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