Niaprazine|27367-90-4|(尼普拉嗪)-陌孚医药/Medlife

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Niaprazine (Synonyms: 尼普拉嗪)

目录号: PL14953 纯度: ≥99%

CAS No. :27367-90-4

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中文名称	Niaprazine
中文别名	尼普拉嗪
英文名称	Niaprazine
英文别名	N-(4-(4-(4-Fluorophenyl)piperazin-1-yl)butan-2-yl)nicotinamide;Niaprazine [INN:DCF];1709 CERM;BRN 0844157;N-(3-(4-(4-Fluorophenyl)-1-piperazinyl)-1-methylpropyl)-3-pyridinecarboxamide;N-(3-(4-(p-Fluorophenyl)-1-piperazinyl)-1-methylpropyl)nicotinamide;Niaprazina;Niaprazina [INN-Spanish];N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide;Niaprazine;3-Pyridinecarboxamide, N-(3-(4-(4-fluorophenyl)-1-piperazinyl)-1-methylpropyl)- (9CI);Niaprazinum;Niaprazinum [INN-Latin];Nicotinamide;Nopron;N-[3-[4-(4-Fluorophenyl)-1-piperazinyl]-1-methylpropyl]-3-pyridinecarboxamide;N-[3-[4-(p-Fluorophenyl)-1-piperazinyl]-1-methylpropyl]nicotinamide
Cas No.	27367-90-4
分子式	C₂₀H₂₅N₄OF
分子量	356.44
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Niaprazine 是一种组胺 H1 受体 (histamine H1-receptor) 拮抗剂。Niaprazine 具有抗组胺和抗血清素活性，并可用于睡眠障碍的研究。
生物活性	Niaprazine is a histamine H1-receptor antagonist. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research.
性状	Solid
体外研究(In Vitro)	Niaprazine exhibits a low affinity for the vesicular monoamine transporter and for D2, α2, β, H1 and mAch receptors. Niaprazine, particularly the (+)stereoisomer, has a higher affinity for α1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, but is poorly recognized by 5-HT1A and 5-HT1B binding sites. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Niaprazine (60 mg/kg; i.p.; once) treatment increases rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Niaprazine also produces a short-lasting depletion of rat brain noradrenaline (NA) and dopamine (DA). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. D Scherman, et al. Molecular pharmacology of niaprazine. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(6):989-1001. [2]. P G Rossi, et al. Niaprazine in the treatment of autistic disorder. J Child Neurol. 1999 Aug;14(8):547-50. [3]. P E Keane, et al. The effect of niaprazine on the turnover of 5-hydroxytry

溶解度数据	In Vitro: DMSO : 100 mg/mL (280.55 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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