Peptide 401 是一种有效的来源于蜂毒中的肥大细胞脱颗粒肽，抑制血管通透性。

Peptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).

Solid

serotonin Histamine Receptor

Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED 50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins). Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, i.e., hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant art

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

IKCNCKRHVIKPHICRKICGKN-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)

Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2 (Disulfide bridge: Cys3-Cys15, Cys5-Cys19)

[1]. Hanson JM, et al. Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.). Br J Pharmacol. 1974 Mar;50(3):383-92.
[2]. Banks BE, et al. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) andcompound 48/80 results from mast cell degranulation in vivo. Br J Pharmacol. 1990 Feb;99(2):350-4.

In Vitro: H₂O : 50 mg/mL (19.33 mM; Need ultrasonic)配制储备液