Lodoxamide|53882-12-5|(洛草氨酸; U-42585E free acid)-陌孚医药/Medlife

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Lodoxamide (Synonyms: 洛草氨酸; U-42585E free acid)

目录号: PL14976 纯度: ≥98%

CAS No. :53882-12-5

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PL14976-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1060.00	请登录

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中文名称	Lodoxamide
中文别名	洛度沙胺;诺朵腊酸;洛草氨酸
英文名称	Lodoxamide
英文别名	Lodoxamide;2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid;Acetic acid,2,2'-((2-chloro-5-cyano-1,3-phenylene)diimino)bis(2-oxo;Alomide (TN);diesters of N,N'-(2-chloro-5-cyano-m-phenylene)dioxamic acid;Lodoxamida;Lodoxamida [INN-Spanish];Lodoxamidum;Lodoxamidum [INN-Latin];N,N'-(2-Chlor-5-cyan-3-phenylen)dioxamsaeure;N,N'-(2-Chlor-5-cyan-m-phenylen)-dioxamsaeure;N-N'-(2-chloro-5-cyano-m-phenylene)dioxamic acid;UNII-SPU695OD73;2,2′-[(2-Chloro-5-cyano-1,3-phenylene)diimino]bis-2-oxoacetic acid
Cas No.	53882-12-5
分子式	C₁₁H₆N₃O₆Cl
分子量	311.63
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Lodoxamide (U-42585E free acid) 是作为肥大细胞稳定剂的抗过敏化合物, 用于研究哮喘和过敏性结膜炎。
生物活性	Lodoxamide (U-42585E free acid) is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.
性状	Solid
体外研究(In Vitro)	Lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced Ca influx with associated histamine release in purified rat peritoneal mast cells. The chemotactic response of eosinophils to fMLP as well as to IL-5 is significant and dose-dependent inhibited by Lodoxamide. Lodoxamide is also able to strongly inhibit the release of eosinophil peroxidase after IgA-dependent activation and, to a lesser extent, the release of eosinophil cationic protein and eosinophil-derived neurotoxin. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep. has not independ
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66(4):286-94. [2]. Capron M,et al. Inhibitory effects of lodoxamide on eosinophil activation. Int Arch Allergy Immunol. 1998 Jun;116(2):140-6. [3]. Barr ML, et al. Addition of a mast

溶解度数据	In Vitro: DMSO : 50 mg/mL (160.45 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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