Zaltidine

(Synonyms: CP-57361)
目录号: PL14954 纯度: ≥99%
Zaltidine(CP-57361)是H2受体拮抗剂,有抗分泌活性。
CAS No. :85604-00-8
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中文名称
Zaltidine
中文别名
唑替丁;Zaltidine
英文名称
Zaltidine
英文别名
Guanidine,N-[4-(2-methyl-1H-imidazol-5-yl)-2-thiazolyl]-;2-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]guanidine;Zaltidine;CP 57361;CP-57361;Zaltidina;Zaltidina [Spanish];Zaltidine HCl;ZALTIDINE HYDROCHLORIDE;Zaltidine hydrochloride [USAN];Zaltidinum;Zaltidinum [Latin];[4-(2-Methyl-1H-imidazol-4-yl)-2-thiazolyl]guanidine
Cas No.
85604-00-8
分子式
C8H10N6S
分子量
222.27
包装储存
Powder -20°C 3 years;4°C 2 years
详情描述
Zaltidine(CP-57361)是H2受体拮抗剂,有抗分泌活性。
产品详情
Zaltidine(CP-57361)是H2受体拮抗剂,有抗分泌活性。
生物活性
Zaltidine(CP-57361) is a H2-receptor antagonist, which has the antisecretory action. IC50 Value: Target: H2 receptor in vitro: in vivo: In eight healthy male volunteers single oral doses of 5 mg, 25 mg and 100 mg produced dose-related inhibition of basal and pentagastrin-stimulated acid output (M.A.O.) with an estimated ID50 of 40 mg for the latter. In eight subjects with duodenal ulceration single 100 mg and 200 mg doses produced 85% and 97% inhibition of M.A.O. at peak (3 h post-dose) and 20% and 23% inhibition at 24 h, respectively; inhibition of basal acid output was 97% at 3 h and 50% at 24 h with both doses [1]. One hundred and thirty-five patients were randomly allocated to 4 weeks treatment with either 150 mg zaltidine once daily or placebo. Fifty-nine were treated for a full 4 weeks with zaltidine before the trial was stopped. Healing rates after 4 weeks of zaltidine and placebo were 86% and 19%, respective
性状
Solid
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Laferla G, Buchanan N, Hearns J, The antisecretory effects of zaltidine, a novel long-acting H2-receptor antagonist, in healthy volunteers and in subjects with a past history of duodenal ulcer. Br J Clin Pharmacol. 1986 Oct;22(4):395-9.
[2]. Farup PG. Zaltidine: an effective but hepatotoxic H2-receptor antagonist. Scand J Gastroenterol. 1988 Aug;23(6):655-8.
溶解度数据
In Vitro: H2O : 7.69 mg/mL (34.60 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)
[1]. Laferla G, Buchanan N, Hearns J, The antisecretory effects of zaltidine, a novel long-acting H2-receptor antagonist, in healthy volunteers and in subjects with a past history of duodenal ulcer. Br J Clin Pharmacol. 1986 Oct;22(4):395-9.
[2]. Farup PG. Zaltidine: an effective but hepatotoxic H2-receptor antagonist. Scand J Gastroenterol. 1988 Aug;23(6):655-8.

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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