Cyclizine|82-92-8|-陌孚医药/Medlife

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Cyclizine

目录号: PL14935 纯度: ≥98%

CAS No. :82-92-8

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中文名称	Cyclizine
中文别名	苯甲嗪;1-二苯甲基-4-甲基哌嗪;赛克;盐酸环素;盐酸环嗪;环己嗪;化合物 T21379
英文名称	Cyclizine
英文别名	Cyclizine;1-benzhydryl-4-methylpiperazine;CYCLIZINE HCL;CYCLYZINE;1-Benzhydryl-4-methyl-piperazin;1-benzhydryl-4-methyl-piperazine;1-diphenylmethyl-4-methylpiperazine;Bw 47-83;Ciclizina;Emoquil;Marazine;Marezine;Marzine;Nautazine;N-benzhydryl-N'-methylpiperazine;Valoid;Wellcome;(n-benzhydryl)(n’-methyl)diethylenediamine;(N-Benzhydryl)(N'-methyl)diethylenediamine;1-(diphenylmethyl)-4-methyl-piperazin;1-Benzhydryl-4-methylpiperazine;1-Diphenylmethyl-4-methylpiperazine;bw47-83
Cas No.	82-92-8
分子式	C₁₈H₂₂N₂
分子量	266.38
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Cyclizine，一种哌嗪衍生物，是一种有效的选择性组胺 H1 受体拮抗剂。Cyclizine 可用于恶心、呕吐和头晕的研究。
生物活性	Cyclizine, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine can be used for the research of nausea, vomiting, and dizziness.
性状	Solid
IC50 & Target[1][2]	H1 Receptor
体外研究(In Vitro)	Cyclizine (100 μM) significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants. Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Cyclizine (1, 10 mg/kg) enhances locomotor activity of mice in a dose-dependent manner. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Naive male CDI mice (Charles River) weighing 25
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Králová J, et, al. The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity. Int Immunopharmacol. 2009 Jul;9(7-8):990-5. [2]. Church MK, et, al. Inhibition of histamine release from human lung in vitro by antihistamines and related drugs. Br J Pharmacol. 1980 Aug;69(4):663-7.

溶解度数据	In Vitro: DMSO : 100 mg/mL (375.40 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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